Table 6.

Enrichment within regulatory networks of Naïve and Primed hESC active enhancers of gene expression signatures (GES) defining embryonic lineages of distinct species.

Human epiblast (EPI) vs naïve hESC (hESCp#0)
Classification category	Number of genes	Percent	P value*	Observed/Expected
Human EPI vs hESCp#0 GES	1496	100.0
Naïve functional enhancers network	762	50.9	1.544E-69	1.73
Primed functional enhancers network	726	48.5	5.669E-73	1.80
Naïve & Primed functional enhancers networks	976	65.2	4.326E-89	1.63
Human epiblast (EPI) vs Trophectoderm (TE) GES
Classification category	Number of genes	Percent	P value*	Observed/Expected
Human EPI vs TE expression signature	836	100.0
Naïve functional enhancers network	525	62.8	1.176E-89	2.13
Primed functional enhancers network	472	56.5	2.095E-73	2.10
Naïve & Primed functional enhancers networks	647	77.4	2.11E-109	1.94
Monkey epiblast (EPI) GES
Classification category	Number of genes	Percent	P value*	Observed/Expected
Monkey EPI expression signature	719	100.0
Naïve functional enhancers network	442	61.5	1.665E-71	2.09
Primed functional enhancers network	399	55.5	1.687E-59	2.06
Naïve & Primed functional enhancers networks	529	73.6	1.003E-75	1.84
Mouse inner cell mass (ICM) vs Trophectoderm (TE)
Classification category	Number of genes	Percent	P value*	Observed/Expected
Mouse ICM vs TE expression signature	497	100.0
Naïve functional enhancers network	246	49.5	2.533E-21	1.68
Primed functional enhancers network	211	42.5	2.314E-14	1.58
Naïve & Primed functional enhancers networks	303	61.0	1.061E-21	1.53

*p values were estimated using the hypergeometric distribution test; expected values were estimated based on the number of genes in the human genome (63,677); number of genes associated with functional enhancers of the Naïve hESC (18,766); number of genes associated with functional enhancers of the Primed hESC (17,131); and number of genes associated with functional enhancers of both Naive and Primed hESC (25,421); GES, gene expression signature.