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. 2021 Mar 26;15:593654. doi: 10.3389/fnins.2021.593654

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Copyright © 2021 Huang, Jiao, Zhu, Xiong, Lu, Ai, Yang, Zhao and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of either DAHP or BH4 intrathecal administration on the expression of three spinal NOS isoforms. (A,B) The expression of spinal iNOS mRNA (F_2,9 = 6.869, P = 0.015) and protein (F_2,9 = 123.036, P < 0.001) in rats treated with DAHP or BH4. (C,D) The expression of spinal eNOS mRNA (F_2,9 = 0.879, P = 0.448) and protein (F_2,9 = 0.081, P = 0.923) in rats treated with DAHP or BH4. (E,F) The expression of spinal nNOS mRNA (F_2,9 = 0.223, P = 0.804) and protein (F_2,9 = 0.131, P = 0.879) in rats treated with DAHP or BH4. Data are shown as mean ± SEM (n = 4). *Significant difference with respect to vehicle groups (one-way ANOVA followed by Bonferroni post hoc test or Dunnett’s T3 test if necessary). *P < 0.05 and **P < 0.01. BH4, tetrahydrobiopterin; NOS, nitric oxide synthase; iNOS, inducible nitric oxide synthase; eNOS, endothelial nitric oxide synthase; nNOS, neuronal nitric oxide synthase.