TABLE 2.
Characteristics of gene studies that found no evidence for effect on lithium response. Only those genes are listed where at least two studies reported the same outcome.
| Gene | Full name | Investigated variants | Number of studies | Total sample size | |
|---|---|---|---|---|---|
| Cases | Controls | ||||
| GSK3β | Glycogen synthase kinase–3β | rs11921360, rs334558, rs3755557 | 5 | 425 | 0 |
| BDNF | Brain-derived neurotrophic factor | rs10835210, rs11030101, rs11030102, rs12273363, rs2030324, rs2049045, rs6265, rs7103411, rs962369, rs988748 | 4 | 658 | 288 |
| SLC6A4 or SERT, 5HTT, 5HTTLPR, HTTLPR | Serotonin transporter | s/s, s/l, I/I | 4 | 470 | 0 |
| HTR2A or 5HT2A | Serotonin receptors 2 A | rs6311, rs6313 | 3 | 348 | 0 |
| DRD2 | Dopamine receptor D2 | rs1799732, VNTR, Ser311Cys, NcoI, TaqIA | 3 | 381 | 0 |
| DRD3 | Dopamine receptor D3 | rs6280, 1/1, 1/2, 2/2, Mscl | 3 | 299 | 0 |
| DRD4 | Dopamine receptor D4 | rs1800955, 2 4, 4 4, 4 7 | 2 | 226 | 0 |
| CLOCK | Circadian locomotor output cycle kaput | rs1801260, rs3736544, rs34897046, rs3805148, rs6849474, rs11932595, rs12648271, rs6850524, rs12649507, rs4340844, rs534654 | 2 | 397 | 0 |
| PER3 | Period circadian clock 3 | rs2304672, rs228729, rs228642, rs228666, rs228697, rs2859388, rs2640909, rs836755, rs228727, rs10864315, rs4908694, rs228682, rs2172563, rs10462021 | 2 | 397 | 0 |
| MAOA | Monoamine oxidase A | 30-bp repeat | 2 | 298 | 108 |
| MMP-9 | Matrix metallopeptidase 9 | rs3918242 | 2 | 210 | 0 |
| NTRK2 | Neurotrophic receptor tyrosine kinase 2 | rs1187326, rs2289656, rs1187327 | 2 | 209 | 0 |
| GNAL | G protein subunit alpha L | A > G in intron 3 and T > G in intron 10 | 2 | 204 | 94 |
| IMPA2 | Inositol monophosphatase 2 | −461C > T, -241_-237dup, −207 T > C, −185 A > G, 97–15G > A, 159 T > C, 230 + 141G > A, 382–44G > A, 443G > A, 490 + 13_14insA, rs3786282, 599 + 97G > A, 599 + 99G > A | 2 | 164 | 0 |