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. 2021 Mar 26;12:653989. doi: 10.3389/fimmu.2021.653989

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Copyright © 2021 Wu, Jiang, Qi, Zhang, Qu and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSK126 inhibits ex vivo activation of IFN-I signaling pathway. (A) Experimental setting for the ex vivo tests. The mice were treated with a single dose of GSK126 (50 mg/kg, i.p.) and then sacrificed after 2 days. Splenocytes were isolated and stimulated with universal type I IFN (1,000 U/ml) for indicated time. (B, C) The levels of ISG15 mRNA (B) and IFIT3 mRNA (C) were measured. (A) Created with BioRender.com. (B, C) Data of three independent experiments are plotted and presented as mean ± SEM. P values were determined by two-way ANOVA.