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. 2021 Mar 26;12:644101. doi: 10.3389/fgene.2021.644101

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Copyright © 2021 Wu, Zhang, Zhou, Zhang, Li, Lv and Liao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematics for the bidirectional Mendelian randomization design. Mendelian randomization requires valid genetic instrumental variants satisfying three assumptions. PCOS, polycystic ovary syndrome.