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. 2021 Mar 26;12:644101. doi: 10.3389/fgene.2021.644101

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Copyright © 2021 Wu, Zhang, Zhou, Zhang, Li, Lv and Liao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Primary results by Mendelian randomization analysis using the inverse-variance-weighted method. The causal estimate (overall fitted line) for the effect of PCOS on periodontitis was shown in panel (A), while the overall effect for the casual association of periodontitis with PCOS was presented in panel (B). Individual SNP-effect on the outcome (point and vertical line) against its effect on the exposure (point and horizontal line) was delineated in the background. CI, confidence interval; IVW, inverse variance weighted; OR, odds ratio; PCOS, polycystic ovary syndrome; SNP, single nucleotide polymorphism.