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. 2021 Mar 23;12:642678. doi: 10.3389/fimmu.2021.642678

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Copyright © 2021 Iwaszkiewicz-Grzes, Piotrowska, Gliwinski, Urban-Wójciuk and Trzonkowski

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global DNA methylation in Tregs and Teffs. Comparison of 5-methylocytosine (5-mC) production in Tregs: POLY, SPEC, UNSPEC and Teffs: POLY, SPEC, UNSPEC. During the tests cells were stimulated with beads anti-CD3/ant-CD28 (index POLY) or monocytes loaded with whole insulin (index INS) or insulin β chain peptide 9-23 (index B:9-23). Cells responding to antigen have an index SPEC, cells not recognizing the antigen have an index UNSPEC. All analyzes were performed for six tests (three tests for whole insulin and three tests for insulin β chain peptide 9-23) in triplicate. The results are presented as mean+/- SD. Significance was calculated using the t- test, significant results are marked with * (p<0.05), ** (p<0.01) or ***(p<0.001).