Table 4.

Selectivity index (SI) for histone modifications.

Histone modification	SI [Teffs/Tregs]
	POLY	SPECINS	UNSPECINS	SPECB:9-23	UNSPECB:9-23
H3K4me1	0,90	1,22	0,93	1,02	1,11
H3K14ac	0,78	1,31	0,49	1,13	2,16
H3K56ac	0,81	1,22	0,72	1,05	1,56
H3K4me3	0,84	1,44	0,73	1,12	1,59
H3K9me2	0,83	1,64	0,51	1,28	1,28
H3K27me1	0,89	2,00	0,53	1,08	1,24
H3K27me3	0,79	1,43	0,75	1,09	1,62
H3K36me2	0,78	1,07	0,60	1,06	1,37
H3K79me1	0,75	1,37	0,47	1,26	1,86
H3K79me3	0,70	1,56	0,67	1,35	1,56
H3ser28P	0,72	2,55	0,80	0,79	3,30
H3K4me2	0,92	1,16	0,82	0,98	1,10
H3K9me1	0,79	1,11	0,82	0,93	1,40
H3K9me3	0,95	0,97	1,07	0,83	1,19
H3K27me2	0,80	0,98	0,61	1,14	1,12
H3K36me1	0,88	1,08	0,67	1,69	1,53
H3K36me3	0,93	1,13	1,04	1,19	1,30
H3K79me2	0,75	1,18	0,87	1,11	1,27
H3K9ac	0,84	1,48	1,08	1,29	1,93
H3K18ac	0,91	1,02	0,91	0,90	1,36
H3ser10P	0,79	1,51	0,88	1,28	1,14

The selectivity index was calculated according to formula $SI=\frac{Teffs}{Tregs}$, where:

Teffs – percentage of histone H3 modification in total H3 in T effector cells.

Tregs – percentage of histone H3 modification in total H3 in T regulatory cells.

green - difference between specific Tregs and Teffs stimulated with insulin;

blue - difference between unspecific Tregs and Teffs stimulated with insulin;

red - difference between unspecific Tregs and Teffs stimulated with peptide 9-23.