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. 2021 Mar 25;12:638010. doi: 10.3389/fimmu.2021.638010

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Copyright © 2021 Shive, Freeman, Younes, Kowal, Canaday, Rodriguez, Lederman and Anthony.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association of plasma levels of TGF-β with T cell markers of exhaustion and senescence in treated, HIV-infected immune non-responders and responders. Representative correlations from Supplemental Table 1 are show. Top row, immune non-responders (INR); Plasma levels of TGF-β (x-axis) vs. CD4+ EM proportion of TIGIT, or CD8+ CM and EM proportions of TIGIT (y-axis). Bottom row, immune responders (IR); Plasma levels of TGF-β (x-axis) vs. CD4+ EM and TEM proportion of PD-1, or CD8+ EM proportions of TIGIT. Correlations were calculated using a Spearman's rank order analysis; p = <0.05 considered statistically significant.