Table 4.
SYRCLE's tool for assessing risk of bias of the studies.
| SYRCLE |
QUALITY ASSESSMENT |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ref. | Sequence generation | Baseline characteristics | Allocation concealment | Random housing | Blinding | Random outcome assessment | Blinding | Incomplete outcome data | Selective outcome reporting | Other sources of bias | Title | Abstract | Introduction | Methods | Results | Discussion | Total |
| Natural scaffolds | |||||||||||||||||
| Li C et al. Sci Rep 2017 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 1 | 3 | 8 | 2 | 2 | 17 |
| Hansen R et al. J Orthop Res 2013 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | YES | YES | NO | 1 | 1 | 2 | 12 | 5 | 3 | 24 |
| Kawaguchi Y et al. Orthop Traumatol Surg Res 2019 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 1 | 1 | 7 | 2 | 2 | 14 |
| Kobayashi Y et al. Am J Sports Med 2010 | NO | YES | NO | NO | UNCLEAR | YES | UNCLEAR | NO | YES | NO | 1 | 2 | 2 | 13 | 3 | 3 | 24 |
| Gastel JA et al. Arthroscopy 2001 | NO | YES | NO | NO | UNCLEAR | YES | UNCLEAR | NO | YES | NO | 1 | 2 | 2 | 13 | 3 | 3 | 24 |
| Cook JL et al. Am J Sports Med 2006 | NO | YES | UNCLEAR | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 1 | 1 | 14 | 3 | 3 | 23 |
| Gruchenberg K et al. Knee Surg Sports Traumatol Arthrosc 2015 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 2 | 1 | 10 | 0 | 0 | 13 |
| Pan Z et al. Acta Biomaterialia 2017 | NO | YES | UNCLEAR | NO | UNCLEAR | UNCLEAR | UNCLEAR | YES | YES | NO | 1 | 2 | 3 | 14 | 6 | 3 | 29 |
| Yuan Z et al. Biomaterials 2016 | NO | YES | UNCLEAR | NO | UNCLEAR | UNCLEAR | UNCLEAR | YES | YES | NO | 1 | 2 | 1 | 11 | 7 | 2 | 24 |
| Peretti GM et al. Am J Sports Med 2004 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 2 | 1 | 9 | 3 | 3 | 18 |
| Martinek V et al. Arch Orthop Trauma Surg 2006 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | YES | NO | YES | 0 | 2 | 1 | 8 | 6 | 3 | 20 |
| Whitehouse MR et al. Stem Cells Transl Med 2017 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 1 | 11 | 2 | 3 | 18 |
| Angele P et al. J Biomed Mater Res 2008 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 1 | 10 | 1 | 1 | 14 |
| Zellner J et al. J Biomed Mater Res Part A 2010 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 1 | 10 | 3 | 1 | 16 |
| Zellner J et al. J Biomed Mater Res Part B Appl Biomater 2013 | NO | YES | UNCLEAR | NO | UNCLEAR | YES | UNCLEAR | NO | YES | NO | 0 | 2 | 2 | 14 | 4 | 2 | 24 |
| Koh RH et al. Acta Biomaterialia 2017 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 2 | 13 | 3 | 3 | 24 |
| Synthetic scaffolds | |||||||||||||||||
| Zhang ZZ et al. Acta Biomaterialia 2016 | NO | YES | NO | NO | UNCLEAR | YES | UNCLEAR | NO | YES | NO | 1 | 2 | 3 | 13 | 5 | 1 | 25 |
| Otsuki S et al. Am J Sports Med 2019 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 1 | 11 | 3 | 3 | 19 |
| Testa Pezzin AP et al. Artif Org 2003 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 1 | 10 | 2 | 2 | 18 |
| Tienen TG et al. Biomaterials 2003 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 1 | 7 | 1 | 2 | 12 |
| Galley NK et al. Clin Orthop Relat Res 2011 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 2 | 3 | 11 | 3 | 0 | 19 |
| Maher SA et al. Arthroscopy 2010 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | YES | YES | NO | 1 | 2 | 2 | 13 | 7 | 1 | 26 |
| Welsing RTC et al. Am J Sports Med 2008 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 2 | 3 | 11 | 5 | 1 | 22 |
| Heijkants RGJC et al. J Mater Sci Mater Med 2004 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 1 | 9 | 3 | 1 | 15 |
| Zhang ZZ et al. Am J Sports Med 2017 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 3 | 12 | 6 | 3 | 25 |
| Gu Y et al. Exp Ther Med 2012 | NO | YES | YES | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 1 | 13 | 3 | 1 | 19 |
| Weinand C et al. Arch Orthop Trauma Surg 2006 | NO | YES | NO | NO | UNCLEAR | YES | UNCLEAR | NO | YES | NO | 1 | 2 | 3 | 12 | 6 | 1 | 25 |
| Weinand C et al. Am J Sports Med 2006 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 2 | 12 | 3 | 2 | 22 |
| Koch M et al. Stem Cell Int 2018 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 2 | 10 | 5 | 2 | 20 |
| Kang SW et al. J Biomed Mater Res 2006 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 2 | 1 | 8 | 4 | 2 | 17 |
| Esposito AR et al. Biores Open Access 2013 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 2 | 1 | 12 | 5 | 3 | 23 |
| Natural/synthetic scaffolds | |||||||||||||||||
| Gao S et al. Acta Biomater 2018 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 3 | 10 | 3 | 3 | 22 |
| Ghodbane SA et al. Tissue Eng Part A 2019 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 2 | 2 | 13 | 6 | 2 | 25 |
| Merriam AR et al. Am J Sports Med 2015 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 2 | 11 | 3 | 2 | 21 |
| Patel JM et al. Am J Sports Med 2016 | NO | YES | NO | NO | UNCLEAR | YES | UNCLEAR | NO | YES | NO | 1 | 2 | 2 | 12 | 6 | 2 | 25 |
| Patel JM et al. Am J Sports Med 2018 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | YES | NO | YES | NO | 1 | 1 | 3 | 14 | 7 | 3 | 29 |
| Patel JM et al. Tissue Eng Part A 2016 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | YES | NO | YES | NO | 1 | 2 | 2 | 11 | 5 | 1 | 22 |
| Chiari C et al. Osteoarthritis Cartilage 2006 | NO | YES | NO | NO | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 0 | 1 | 2 | 11 | 1 | 3 | 18 |
| Nakagawa Y et al. Am J Sports Med 2019 | NO | YES | NO | YES | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 1 | 3 | 11 | 2 | 0 | 18 |
| Cojocaru DG et al. J Biomed Mater Res 2020 | NO | YES | NO | YES | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 3 | 13 | 7 | 0 | 26 |
| Demirkiran ND et al. Acta Orthop Traumatol Turc 2019 | NO | YES | NO | YES | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 3 | 13 | 3 | 3 | 25 |
| Shimomura K et al. Biomaterials 2019 | NO | YES | NO | YES | UNCLEAR | YES | UNCLEAR | NO | YES | NO | 0 | 2 | 2 | 13 | 3 | 2 | 22 |
| Moradi L et al. Biomaterials 2017 | NO | YES | NO | YES | UNCLEAR | UNCLEAR | YES | NO | YES | NO | 1 | 2 | 3 | 13 | 2 | 2 | 23 |
| Chen C et al. Am J Sports Med 2020 | NO | YES | NO | YES | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 2 | 14 | 1 | 1 | 21 |
| Kon E et al. Tissue Eng Part A 2008 | NO | YES | NO | YES | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 3 | 13 | 3 | 3 | 25 |
| Kon E et al. Tissue Eng Part A 2012 | NO | YES | NO | YES | UNCLEAR | UNCLEAR | UNCLEAR | NO | YES | NO | 1 | 2 | 2 | 14 | 3 | 3 | 25 |