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. 2021 Mar 25;8:635245. doi: 10.3389/fmolb.2021.635245

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Copyright © 2021 Borah, Deb, Al-Shar’i, Dahabiyeh, Venugopala, Singh, Shinu, Hussain, Deka, Chandrasekaran and Jaradat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construct of two types of RNA vaccines: (A) A typical conventional mRNA construct with Cap, untranslated regions (UTRs), antigen of interest, and poly-A tail; (B) self-amplifying mRNA or Replicons construct with the sequences of non-structural proteins (NSPs) derived from another virus (e.g. Alpha virus) introduced between the 5ʹ-UTR and the antigen of interest.