TABLE 1.

Summary of BST-CRH signaling studies.

Neurotransmitter/Neuropeptide	Target receptor	Target region	Treatment	Effect
5-HT	5-HT1A	BSTd	Activation of 5-HT DRD projections	↓ Anxiety-like behavior (Garcia-Garcia et al., 2018)
	5-HT2c	BST	Activation of 5-HT DRD projections	↑ Anxiety-like behavior (Marcinkiewcz et al., 2016)
OT	OTR	BSTam	OTR antagonist administration	↓ Stress-induced social avoidance in female mice (Duque-Wilckens et al., 2018)
AVP	V1aR	BSTmv	V1aR antagonist administration	↑ Sex and context–specific anxiety-like behavior (Duque-Wilckens et al., 2016)
	V1bR	Pituitary	Immobilization stress	↑ HPA axis activation (Dinan and Scott, 2005)
HCRT	—	BSTadl	BST-CRH activation of HCRT neurons	↑ Anxiety-like behavior and arousal (Giardino et al., 2018)
NPS	NPSR	—	i.c.v. NPS administration	↓ Anxiety-like behavior, ↑ arousal (Xu et al., 2004)
		lateral ventricle	CRHR1 antagonist and NPS administration	No increase in self-administered cocaine use (Pañeda et al., 2009)
PACAP	PAC1R	BSTov	Chronic variable mild stress paradigm	↑ Number of PACAP expressing cells in the BSTov (Hu et al., 2020)
		BST	i.c.v. PACAP infusion	↑ Anxiety-like behavior (Hammack et al., 2009a)
		BST	PAC1R antagonist administration	Blocked excessive alcohol consumption in dependent rats (Ferragud et al., 2020)
		BSTp	PACAP agonist administration	↑ Weight loss in rats (Kocho-Schellenberg et al., 2014)
PKC-∂	—	BSTov	Optogenetic activation of BSTov PKC-∂ neurons	↓ Feeding behavior (Wang et al., 2019)
Glutamate	NMDAR	BSTdl	Deletion of GluN2D subunit	↑ Depressive-like behavior (Salimando et al., 2020)
	AMPAR	BSTdl	Adolescent intermittent ethanol vapor exposure	↓ GluA2 subunit expression (Kasten et al., 2020)
NPY	Y1R	BST	Y1R activation	↓ Binge alcohol drinking (Pleil et al., 2015)
	Y2R	Lateral ventricle	Y2R antagonism	↓ Alcohol consumption (Thorsell et al., 2002)
β-E	μ and δ opioid receptors	BST	β-E deficient mice	↑ Alcohol consumption in female mice (Nentwig et al., 2019)
NE	α2a-AR	BSTd	α2a-AR agonist administration	↓ Anxiety-like behavior (Schweimer et al., 2005; Harris et al., 2018)
	β-AR	BST	NE administration	↑ CRH neuron activation (Snyder et al., 2019)
DA	D1R, D2R	BSTdl	DA administration	↑ glutamatergic transmission (Kash et al., 2008)
eCB	CB1R	BSTd	MAG lipase inhibitor administration	Normalized BST CRH neuron activation following alcohol withdrawal (Centanni et al., 2019)

—Indicates value not specified by cited paper.