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. 2021 Mar 19;9:653381. doi: 10.3389/fcell.2021.653381

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Copyright © 2021 Xie, Liang, Yu and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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N-terminal coiled coils mediate the self-assembly of liprin-α. (A) The solved structures of liprin-α N-terminus were indicated by black boxes. The H2 (PDB id: 7D2H), H3 (7D2E), and SAH (6IUH) segment structures of liprin-α2 were shown. (B) A model indicating that the dimeric H2 and H3 competitively transit between homo-tetramers and a H23-dimer. (C) A schematic cartoon showing the self-assembly mechanism of liprin-α CC1. The transition between dimers and higher oligomers may be controlled by unknown regulators. (D) A structure model showing the complete N-terminal structure of liprin-α. The H1 segment and CC2 was modeled as coiled coils and shown in gray.