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. 2021 Mar 19;9:653381. doi: 10.3389/fcell.2021.653381

FIGURE 4.

FIGURE 4

Additional regions of liprin-α in protein–protein interactions. (A) The structure of the LCR in complex with mDia (PDB id: 4UWX). Base on another solved structure of mDia (PDB id: 2BAP), the surface on mDia that is involved in the autoinhibition formation was highlighted by a dotted hotpink circle, showing the two binding sites are largely overlapped. (B) The structure of the PBM in complex with the PDZ6 domain of GRIP1 (PDB id: 1N7F). (C) The manually modeled structure of the PP2A-B56/liprin-α_PBBM complex. The sequences of the PBBMs from different proteins in the solved structures were aligned with the PBBMs of liprin-αs. The residues that are involved in B56 binding were highlighted by red boxes.