TABLE 1.

Interactions meditated by liprin-α family members.

Interactor	Liprin-α family member	Interaction region	Cellular function	References
LAR, PTPδ, PTPσ Dlar PTP-3	α1, 2, 3, 4 Dliprin-α SYD2	SAM123	Synaptogenesis, neuron development, acrosome reaction	Serrapages et al., 1995; Serra-Pages et al., 1998; Kaufmann et al., 2002; Wyszynski et al., 2002; Ackley et al., 2005; Dunah et al., 2005; Astigarraga et al., 2010; Kiok et al., 2011; Joshi et al., 2014; Bomkamp et al., 2019; Wakita et al., 2020; Xie et al., 2020
CASK	α1, 2, 3, 4	SAM123	Neurotransmitter release	Olsen et al., 2005; Samuels et al., 2007; Wei et al., 2011; LaConte et al., 2016; Wu et al., 2016
Liprin-β1	α1, 2, 3 Dliprin-α SYD2	SAM123	Synaptogenesis, cell motility	Serra-Pages et al., 1998; Astigarraga et al., 2010; Wei et al., 2011; Chiaretti et al., 2016
mSYD1A SYD1	α2 SYD2	SAM123	Active zone formation	Chia et al., 2012; Owald et al., 2012; Wentzel et al., 2013; McDonald et al., 2020
RSY-1	SYD2	SAM123	Regulation of presynaptic assembly	Patel and Shen, 2009; Chia et al., 2013
CAMKIIα	α1	SAM123	Synapse morphogenesis	Hoogenraad et al., 2007
Unc13B	Dliprin-α	Coiled-coil region	Active zone formation	Bohme et al., 2016
Liprin-γ	Dliprin-α	Coiled-coil region	Synaptogenesis	Astigarraga et al., 2010
KIF1A Kinesin-3	α1,2, Dliprin-α SYD2	Coiled-coil region	Synaptic vesicles transport	Shin et al., 2003; Wagner et al., 2009; Stucchi et al., 2018
Tanc2	α2	Coiled-coil region	Postsynaptic development	Stucchi et al., 2018
Liprin-α	α1, 2, 3, 4 SYD2	Coiled-coil region	Presynaptic formation	Serra-Pages et al., 1998; Taru and Jin, 2011; Astro et al., 2016
RIM1	α3, 4	CC2	Neurotransmitter release	Schoch et al., 2002
ELKS, CAST	α1,2,3,4 SYD2	CC2	Active zone formation	Ko et al., 2003b; Dai et al., 2006; Kittelmann et al., 2013
GIT1	α1, 2, 3, 4 Dliprin-α SYD2	SAH	AMPA receptor targeting, cell spreading	Ko et al., 2003a, b; Totaro et al., 2007; Asperti et al., 2011; Liang et al., 2019; McDonald et al., 2020
mDia	α1, 3	LCR	Stress fiber formation	Sakamoto et al., 2012; Brenig et al., 2015
GRIP1	α1, 2, 3, 4	PBM	AMPA receptor targeting	Wyszynski et al., 2002; Im et al., 2003; Zurner and Schoch, 2009; Chatterjee and Roy, 2017
LNX1	α1,2,3	PBM	Ubiquitination of liprin-α	Lenihan et al., 2017a, b
PP2A B56γ	α1 Dliprin-α	PBBM	Regulation of synaptic materials in distal axons	Arroyo et al., 2008; Li et al., 2014
PP2Aα	α1	Unknown	Trafficking to the ciliary tip, Hedgehog signaling	Liu et al., 2014
Kinesin-1	Dliprin-α	Unknown	Synaptic vesicles transport	Miller et al., 2005
KIF7	α1	Unknown	Trafficking to the ciliary tip, Hedgehog signaling	Liu et al., 2014
ING4	α1	Unknown	Cell growth and motility	Unoki et al., 2006; Shen et al., 2007
α-Dystrobrevin-1	α1	Unknown	Neuromuscular junction development	Gingras et al., 2016; Bernadzki et al., 2017
PSD95	α1	Unknown	Postsynaptic organization	Huang et al., 2017
CDK5	α1	Unknown	Postsynaptic organization	Huang et al., 2017
PARP1	α1	Unknown	P65 transcriptional activation	Gu et al., 2019
EphA2	α1	Unknown	Cell motility	Buraschi et al., 2020