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. 2021 Apr 2;13(14):16007–16018. doi: 10.1021/acsami.0c21994

Figure 1.

Figure 1

Synthesis and characterization of PIC immunobrush beads. (a) Schematic overview of the preparation of PIC brush beads (top), Ab beads (bottom left), flat PIC beads (bottom center), and cross-linked PIC beads (bottom right). (b, c) Production of IFNγ (b, n = 3 in two independent experiments) and IL-2 (c, n = 4 in two independent experiments) after 20–24 h of human T cells stimulated with directly coupled antibody beads or PIC beads. (d) Mean cell cycle of proliferated human T cells on day 3, stimulated directly coupled antibody beads or PIC beads n = 4 in two independent experiments. (b–d) A paired t test was performed on log2-transformed data. (e, f) IFNγ and IL-2 production of human T cells after 20–24 h stimulated with PIC beads with reduced mobility, n = 2 in one independent experiment. An RM one-way analysis of variance (ANOVA) was performed on log2-transformed data with Geisser–Greenhouse correction, followed by Dunnett’s multiple comparison test.