Table I. Approaches to management of early-stage serous endometrial cancer.

VB: Vaginal brachytherapy; EBRT: external beam radiation. *Comparing early-stage, high-risk endometrial cancer (15% serous) vs. VB + chemotherapy, found increased hazard ratio for pelvic or peri - aortic nodal recurrence in VB + chemotherapy at 3 years; no difference in overall survival was noted in subgroup analysis of patients with stage I serous disease. **Compared with EBRT alone in women with high-risk endometrial cancer, finding increased progression-free and overall survival with the addition of chemotherapy. Due to lack of statistical power, it was not possible to analyze survival stratified by stage in serous cancer.