Skip to main content
. Author manuscript; available in PMC: 2021 Apr 14.
Published in final edited form as: Genes Brain Behav. 2019 Aug 13;19(3):e12601. doi: 10.1111/gbb.12601

Figure 1. Dose-response relationships for stress-induced reinstatement of nicotine CPP in male and female mice.

Figure 1.

(a) Timeline for CPP conditioning, acquisition, post-abstinence, extinction, and stress-induced reinstatement. Arrows indicate test days for which data are represented in (b) and (c) for male and female mice, respectively. Significant stress-induced reinstatement of nicotine CPP is seen for male mice trained with 0.5 mg/kg nicotine and for female mice trained with 0.5 mg/kg and 0.75 mg/kg nicotine. *p < 0.05 compared to pretest day within nicotine dose using Dunnett’s tests.