Figure 3. Guanfacine produced variable responses to stress-induced reinstatement in male and female mice.

Separate two-way ANOVAs within sex showed (a) a significant interaction of conditioning group and pre-stress treatment in male mice, and a near-significant difference between control- and nicotine-conditioned mice receiving saline pre-treatment. (b) No significant main effects or interactions were observed in female mice. S = saline, G = guanfacine