Scheme 3.

Synthetic schemes for the preparation of [4′−2H]-4′-deoxy-4′-fluoro-paromamine (16), (3′S)-3′-deoxy-3′-fluoro-paromamine (17) and (3′R)-3′-deoxy-3′-fluoro-paromamine (18).

Synthetic schemes for the preparation of [4′−2H]-4′-deoxy-4′-fluoro-paromamine (16), (3′S)-3′-deoxy-3′-fluoro-paromamine (17) and (3′R)-3′-deoxy-3′-fluoro-paromamine (18).