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Expression levels of apoptosis-associated proteins. (A) Relative protein expression levels of cleaved caspase-3, cleaved caspase-8 and cleaved PARP. *P<0.05 vs. TRAIL. Some bars are not shown since no cleaved protein was detected. (B) Antitumor activity of TRAIL-Mu3 and TRAIL at 2, 4 and 6 h. **P<0.001 and ***P<0.0001 vs. TRAIL. TRAIL-Mu3, recombinant TNF-related apoptosis-inducing ligand; PARP, poly (ADP-ribose) polymerase.
