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The number of studies and the percentage (%) detecting significant change in systemic levels of IFA-related biomarkers.
| IFA biomarker | Number of studies/% detecting significant change | |
|---|---|---|
| Serum/Plasma | CSF | |
| IL-6 | 18/60 | 21/52 |
| CRP | 14/71 | a |
| TNF-α | 30/87 | 16/56 |
| IL-1Ra | 2/50 | 2/50 |
| IL-10 | 10/60 | 8/63 |
a One study [179] confirmed a raised level of CRP that was not significantly different from control values.
