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. 2021 Apr 13;26:14. doi: 10.1186/s11658-021-00258-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Impact of CDKN2B-AS1 variant on survival. a Principal component analysis plots the interactions of variables. Each arrow represents a variable with a longer length indicating a greater impact on distribution of the samples. Each observation is symbolized as a triangle (if it has short overall survival) or circle (if it has prolonged survival). Mortality was associated with A/A and A/G genotypes. They were more likely to have ER/PR− and HER2⁺ receptors and multiple foci. b Kaplan–Meier curve showing the mean and confidence interval duration of overall survival according to their genotype status. G/G homozygote patients had longer survival than their counterparts (P < 0.001)