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. 2021 Apr 13;14:103. doi: 10.1186/s12920-021-00953-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Meta-analysis of TNF SNPs associated with acne presentation and acne severity grades. a Subgroup meta-analysis of association of rs1800629 with acne presentation among Asians and Caucasians. b Subgroup meta-analysis of association of rs1800629 with acne severity among different grades. c Meta-analysis of association of rs361525 with acne presentation. Only gene variants that were investigated in at least two other previous studies were included in the meta-analysis. Analysis was performed under allele model (minor allele vs. major allele)., i.e. A versus G for both rs1800629 and rs361525