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. 2021 Mar 12;12:628758. doi: 10.3389/fgene.2021.628758

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Copyright © 2021 Iqbal, Demidova, Serrao, ValizadehAslani, Rosen and Arora.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan-Meier curves for OS and DFS in breast cancer (BC) (A,B) and its subtypes (C–G) studies with RRM2B amplifications and/or MYC amplifications. (A) OS in BC cases. The cases that were unaltered for both genes (black, n = 737), cases with RRM2B amplifications (red, n = 14), cases with MYC amplifications (blue, n = 62) and co-amplifications (pink, n = 210) were plotted. (B) DFS in BC cases. The cases that were unaltered for both genes (black, n = 678), cases with RRM2B amplifications (red, n = 12), cases with MYC amplifications (blue, n = 55) and co-amplifications (pink, n = 184) were plotted. (C) OS in ER + PR + HER2 + BC cases. The cases that were unaltered for RRM2B (black, n = 68), cases with RRM2B amplifications (salmon, n = 18). (D) DFS in ER + PR + HER2 + cases. The cases that were unaltered for RRM2B (black, n = 63), cases with RRM2B amplifications (red, n = 13). (E) OS in BC subtypes with RRM2B amplifications. ER + PR + HER2 + cases with amplifications in RRM2B (purple, n = 18), ER- PR- HER2- cases with amplifications in RRM2B (blue, n = 26), and ER + PR + HER2- cases with amplifications in RRM2B (peach, n = 36). (F) DFS in BC subtypes with RRM2B amplifications. ER + PR + HER2 + cases with amplifications in RRM2B (purple, n = 13), ER- PR- HER2- cases with amplifications in RRM2B (blue, n = 25), and ER + PR + HER2- cases with amplifications in RRM2B (peach, n = 34). The plots were compared using Log-rank test and significance is shown as follows: *P < 0.05, **P < 0.01, and ***P < 0.001. (G) P-values for the graphs (E,F).