Fig. 1.

a Study workflow. b Circos plot of the selected genes on the chromosome. c Gene co-expression network of the m6A-related genes. The gene pairs with Pearson r > 0.3 are considered to have co-expression correlation. d Discrimination analyses of the tumor and adjacent normal tissues in pan-cancer (cancer types with ≥5 tumor-normal pairs included) based on the m6A gene panel. In the principal components plot of the m6A gene panel in lung cancer tumor/normal tissues, the area under the curve (AUC) of distinguishing between tumor and normal tissues is 0.96 (95% CI: 0.93–0.98). e Heatmap of the somatic mutation frequency of the genes across pan-cancer