Table 1.
STAT3 isoforms
| STAT3 isoform | Molecular weight (kDa) | Structure | Function | References |
|---|---|---|---|---|
| STAT3α | 92 | Full length | Typical STAT3 function | [47] |
| STAT3β | 83 | C-terminal truncated form (missing Ser727) | Greater DNA binding activity; Distinct regulatory and transcriptional functions; Suppressive effect on STAT3 | [51] |
| STAT3γ | 72 | C-terminal truncated form (missing Ser727and Tyr705) | Activated in the terminal stage of granulocytic differentiation | [48] |
| STAT3δ | 64 | C-terminal truncated form (missing Ser727 and Tyr705) | Activated in the early stage of granulocytic differentiation | [48] |