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. 2021 Apr 13;19:117. doi: 10.1186/s12957-021-02226-1

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© The Author(s) 2021, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Colorectal cancer cell migration and invasion were suppressed by miR-490-3p. a Three mimic sequences and inhibitor sequences were used, and the most effective inhibitor and mimics were selected in the following experiments. b The knockdown model of miR-490-3p in SW480 cell line and overexpressed model of miR-490-3p in LOVO cell line were established. c The cell migration and invasion of colorectal cancer cells were measured after LV-inhibitor treatment. d The cell migration and invasion of colorectal cancer cells were increased significantly after miR-490-3p was knockdown. e The cell migration and invasion of colorectal cancer cells were measured after LV-mimics treatment. f After treatment with LV-mimics, cell migration and invasion were remarkably suppressed