Table 2.
Top 50 methylated adipose loci in the highly burdened veterans, ordered by q-value
| CpG | Chromosome | Gene | Regression Coeff. | pval | qval |
|---|---|---|---|---|---|
| cg18447419 | 5 | SLC9A3 | −0.0951 | 1.07E-07 | 0.052 |
| cg04350571 | 8 | LYNX1 | −0.0201 | 5.97E-07 | 0.100 |
| cg04939944 | 7 | TNRC18 | −0.0302 | 6.20E-07 | 0.100 |
| cg26351451 | 4 | KIAA1239 | 0.0364 | 1.10E-06 | 0.134 |
| cg10831901 | 20 | LOC149837 | −0.0773 | 1.44E-06 | 0.140 |
| cg07327335 | 2 | PP14571,GPC1 | −0.0466 | 1.91E-06 | 0.155 |
| cg09130535 | 11 | ADRBK1 | −0.0197 | 3.11E-06 | 0.213 |
| cg14633910 | 6 | SYCP2L | −0.0253 | 4.40E-06 | 0.213 |
| cg25679766 | 6 | 0.0315 | 4.43E-06 | 0.213 | |
| cg18584639 | 5 | 0.0346 | 4.54E-06 | 0.213 | |
| cg23045716 | 4 | LOC100130872,LOC100130872-SPON2 | 0.0227 | 5.10E-06 | 0.213 |
| cg21726840 | 19 | PRAM1 | 0.0237 | 5.26E-06 | 0.213 |
| cg26132511 | 6 | ZFAND3 | 0.0231 | 8.33E-06 | 0.292 |
| cg12520727 | 11 | CLPB | −0.0226 | 8.78E-06 | 0.292 |
| cg01026256 | 3 | VWA5B2,MIR1224 | −0.0441 | 9.11E-06 | 0.292 |
| cg13983779 | 9 | −0.0245 | 9.63E-06 | 0.292 | |
| cg06647068 | 12 | CHST11 | −0.0341 | 1.14E-05 | 0.314 |
| cg10422455 | 11 | MRGPRX2 | 0.0252 | 1.16E-05 | 0.314 |
| cg05361530 | 16 | 0.0217 | 1.31E-05 | 0.320 | |
| cg07392385 | 10 | SORCS1 | −0.0327 | 1.34E-05 | 0.320 |
| cg13689342 | 21 | 0.0202 | 1.42E-05 | 0.320 | |
| cg09977640 | 17 | −0.0291 | 1.55E-05 | 0.320 | |
| cg13905238 | 3 | −0.0310 | 1.55E-05 | 0.320 | |
| cg05060534 | 13 | TFDP1 | −0.0140 | 1.61E-05 | 0.320 |
| cg16156617 | 6 | SLC17A4 | 0.0212 | 1.67E-05 | 0.320 |
| cg09897374 | 6 | 0.0364 | 1.72E-05 | 0.320 | |
| cg17094014 | 6 | MDFI | −0.0219 | 1.88E-05 | 0.338 |
| cg07325692 | 7 | 0.0268 | 2.08E-05 | 0.351 | |
| cg25195158 | 12 | −0.0274 | 2.15E-05 | 0.351 | |
| cg18099408 | 3 | STAB1 | 0.0304 | 2.22E-05 | 0.351 |
| cg20266320 | 1 | −0.0330 | 2.31E-05 | 0.351 | |
| cg26284544 | 19 | SNAPC2 | −0.0678 | 2.38E-05 | 0.351 |
| cg04307083 | 4 | HOPX | 0.0190 | 2.38E-05 | 0.351 |
| cg09167779 | 5 | MCC | 0.0200 | 2.48E-05 | 0.354 |
| cg13731106 | 9 | 0.0257 | 2.78E-05 | 0.358 | |
| cg21207003 | 3 | QTRTD1 | −0.0198 | 2.82E-05 | 0.358 |
| cg10891482 | 11 | MS4A8B | 0.0226 | 3.01E-05 | 0.358 |
| cg01540102 | 16 | DOK4 | −0.0285 | 3.03E-05 | 0.358 |
| cg11404049 | 1 | CASP9 | −0.0141 | 3.10E-05 | 0.358 |
| cg08644276 | 2 | 0.0265 | 3.12E-05 | 0.358 | |
| cg16763089 | 20 | LOC149837 | −0.0868 | 3.17E-05 | 0.358 |
| cg15791105 | 12 | COL2A1 | 0.0159 | 3.18E-05 | 0.358 |
| cg25965864 | 12 | LRRC23 | −0.0235 | 3.25E-05 | 0.358 |
| cg07860645 | 6 | DAAM2 | −0.0234 | 3.37E-05 | 0.358 |
| cg16673904 | 17 | SHBG | 0.0199 | 3.39E-05 | 0.358 |
| cg23477257 | 7 | PHTF2 | 0.0214 | 3.39E-05 | 0.358 |
| cg05053979 | 14 | FOXN3 | −0.0352 | 3.59E-05 | 0.365 |
| cg01330280 | 6 | HIST1H3H,HIST1H2BL | −0.0547 | 3.65E-05 | 0.365 |
| cg15147215 | 3 | STAB1 | 0.0218 | 3.83E-05 | 0.365 |
| cg09357935 | 11 | SLC6A5 | −0.0453 | 3.85E-05 | 0.365 |
Data generated from a linear model with empirical Bayes estimation, which we used for the adipose tissue DNA methylation beta value comparisons between the Ranch Hand veterans with high serum TCDD levels (n = 11) and the control group (n = 12). The q-value was calculated using the Benjamini-Hochberg method. The regression coefficient identifies the direction of methylation change between the burden groups and was determined via the model we constructed. Genes associated with each CpG are also given in the table