Table 3.

Regions of adipose tissue DNA altered in the high burden group compared to the control that resulted in a minimum adjusted p-value < 10^− 6

Chrm.	Number of CpGs	pval	Stouffer-adjusted pval	Max beta-fold change	Mean beta-fold change	Overlapping Genes
2	9	8.26E-15	1	−0.077	− 0.057	SNORA64, SNORA12, SNORA74, SNORA19, PAX8-AS1, snR65, 5S_rRNA, SNORA4, SNORD11, SNORD51, SNORA41, SCARNA6, SNORD39, SNORA75, ACA59, PAX8, SNORA48, SNORD56, SNORA43, SNORA1, Vault
13	5	8.32E-13	1	−0.046	−0.038	SNORD36
1	8	7.11E-11	1	−0.058	−0.027	snoU13, Y_RNA, SCARNA16, U1, SCARNA17, SCARNA18, SCARNA24, SNORD112, SNORA62, SNORA63, C1orf50, SNORD46, SNORA2, SNORD81, U3, SNORA51, SNORA25, SCARNA20, SNORA67, U6, SNORA70, SNORA77, SNORA26, U8, SCARNA11, SNORA31, SNORA42, SNORA40, SNORD64, ACA64, snoU109, SNORD60, SNORD116
20	9	7.97E-11	1	−0.076	−0.053	LINC00654
6	21	3.67E-09	1	−0.050	−0.024	SNORA38, LY6G5C, SNORA20
19	25	1.76E-08	1	−0.035	−0.011	USP29
1	5	1.83E-08	1	−0.058	− 0.044	snoU13, Y_RNA, SCARNA16, SCARNA21, U1, SCARNA17, SCARNA18, SCARNA24, SNORD112, SNORA62, SNORA63, SNORD46, SNORA2, SNORD81, U3, SNORA51, SNORA25, SCARNA20, SNORA67, U6, SNORA70, SNORA77, SNORA26, U8, SCARNA11, SNORA31, SNORA42, SNORA40, SNORD64, ACA64, snoU109, SNORD60
5	12	2.98E-08	1	−0.068	−0.014	SLC9A3
17	12	6.86E-08	1	−0.058	−0.025	C17orf107, CHRNE
7	16	9.88E-08	1	0.071	0.013	YWHAG
11	10	1.61E-07	1	−0.042	−0.030	LSP1, SLC6A5

Data generated using the DMRcate algorithm from Bioconductor. The “pval” is a minimum adjusted p-value generated by the DMRcate algorithm, and we used a significance cutoff of 1e-6 when comparing methylation across the adipose tissue DNA regions in the Ranch Hand veterans with high serum TCDD (n = 11) levels compared to the control group (n = 12). The Stouffer-adjusted p-value is also calculated by DMRcate. The max and mean beta-fold change indicate differences in methylation levels between the highly burdened and control groups. The “Overlapping Genes” column indicates the genes associated with the region of DNA studied