Table 6.

Dressing- and medical-related expenses per patient per year

Citation, study design	Country	Patient population	Sample size, N	Cost per patient per yeara	Cost year	Definition
Dressing costs
Jeon [59]	South Korea	RDEB	13	$4296	2016 USDc	Dressings, fixing materials, topical agents and medicines used during changes
Patient surveyb
Mellerio [62]	United Kingdom	RDEB	40	$9049	2016 GBPc	Cost of dressing
Patient and caregiver surveyb		RDEB, severe	17	$17,151		Cost of dressings
		RDEB	11	$15,293		Cost of hours spent dressing wounds
Grocott [76], single-center, cross-sectional surveyb	United Kingdom	RDEB, with wounds difficult to manage with conventional dressings	11	$28,727	2012 GBP	Dressing materials, costs estimated via monthly dressing orders
Kirkorkian [77],	United States	RDEB, neonate	NA	$4,000–$47,000	2014 USD	Cost of wound care products obtained from Amazon.com (August 2012 prices) based on body-size
Cost exercise model		RDEB, infant		$8,000–$99,000
		RDEB, 10 year old		$20,000–$245,000
Flannery [78], Patient surveyb	Ireland	EB	5 (4 RDEB)	$32,256	2020 EURc	Median wound and drugs cost
Medical, non-dressing-related costs
Jeon [59], Patient surveyb	South Korea	RDEB	13	$3096	2016 USD	All RDEB expenses excluding dressing costs
Mellerio [62], Patient and caregiver surveyb	United Kingdom	RDEB	10	$1249d	2016 GBPc	Cost per hospital stay, assuming ₤212 per day
Flannery [78], Patient surveyb	Ireland	EB	5 (4 RDEB)	$84,534	2020 EURc	Median total medical costs
				$33,679		Median overnight hospital costs, assuming €813 per night
				$2890		Median day clinic costs, assuming €407 per visit
				$1304		Median other primary care costs, including GP visits, physiotherapy, occupational therapy, public health nurse visits

GBP, British pound sterling; GP, general practitioner; EB, epidermolysis bullosa; EUR, euro; NA, not applicable; NR, not reported; RDEB, recessive dystrophic epidermolysis bullosa; USD, United States dollar

^aAll costs converted to USD based on November 5, 2020 exchange rate

^bPatient surveys were used to gather healthcare resource utilization and then local unit costs were applied to generate cost estimates

^cYear of currency not defined, assumed to be publication year

^dCost reported per hospital stay not per year