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. Author manuscript; available in PMC: 2021 Dec 4.
Published in final edited form as: Semin Immunol. 2020 Dec 4;49:101436. doi: 10.1016/j.smim.2020.101436

Figure 1. Structure and signaling of TIM-3.

Figure 1.

1) In the absence of TIM-3 ligands, BAT3 binds the TIM-3 cytoplasmic tail and recruits the active form of LCK to the TCR complex to activate TCR signaling. 2) In the presence of ligand, BAT3 is released from the TIM-3 cytoplasmic tail, resulting in the recruitment of phosphatases, dephosphorylation of LCK, and inhibition of TCR signaling. Tyrosine kinase FYN can be recruited to the TIM-3 tail after the release of BAT3. 3) TIM-3 blockade may promote TIM-3-BAT3 interaction and TCR signaling.