Table 3.
Impact of the characteristics of hospitalized COVID-19 patients on IFN-γ response induced by pools N, M, S and MegaPool.
| Characteristics | SEB |
Pool S |
MegaPool |
Pool N |
Pool M |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| median (IQR) | rs | p | median (IQR) | rs | p | median (IQR) | rs | p | median (IQR) | rs | p | median (IQR) | rs | p | ||
| Gender | Male | 10.7 (1.1–12.0) | na | 0.849 | 1.8 (0.2–2.8) | na | 0.329 | 1.4 (0.6–5.6) | na | 0.369 | 0.3 (0.0–1.1) | na | 0.551 | 0.3 (0.0 – 0.7) | na | 0.457 |
| Female | 10.8 (2.1–12.1) | 0.4 (0.1–2.1) | 0.7 (0.2–4.4) | 0.1 (0.0–1.7) | 0.1 (0.0 – 0.9) | |||||||||||
| Age | na | −0.14 | 0.349 | na | 0.0 | 0.996 | na | 0.01 | 0.947 | na | −0.01 | 0.637 | na | −0.04 | 0.790 | |
| Cortisone | No | 10.4 (2.7–12.0) | na | 0.710 | 1.0 (0.3–2.2) | na | 0.515 | 1.0 (0.2–4.6) | na | 0.954 | 0.2 (0.0–1.7) | na | 0.953 | 1.1 (0.0 – 0.5) | na | 0.086 |
| Yes | 10.9 (1.1–12.1) | 0.6 (0.2–2.2) | 1.4 (0.3–4.7) | 0.3 (0.0 – 0.8) | 0.3 (0.0–1.4) | |||||||||||
| Days from symptom onset* | na | 0.12 | 0.467 | na | 0.07 | 0.670 | na | 0.1 | 0.655 | na | 0.01 | 0.958 | na | 0.19 | 0.232 | |
| Severity of diseasea | Mild/Moderate | 10.9 (10.8–13.4) | na | 0.598 | 1.2 (0.3–2.9) | na | 0.478 | 4.0 (1.3–5.6) | na | 0.195 | 0.8 (0.1–1.6) | na | 0.242 | 0.4 (0.2 – 0.5) | na | 0.260 |
| Severe | 10.6 (1.5–12.1) | 0.4 (0.1–3.1) | 1.4 (0.2–6.1) | 0.2 (0.0–1.1) | 0.5 (0.0–1.8) | |||||||||||
| Critical | 6.8 (0.8–11.9) | 0.9 (0.2–2.0) | 0.9 (0.0–2.9) | 0.2 (0.0 – 0.3) | 0.0 (0.0 – 0.3) | |||||||||||
| Lymphocytes (x103) | Number | na | 0.31 | 0.037 | na | 0.02 | 0.872 | na | 0.16 | 0.286 | na | 0.17 | 0.260 | na | 0.30 | 0.048 |
| Serology | IgG index | na | 0.29 | 0.052 | na | 0.10 | 0.503 | na | 0.18 | 0.219 | na | 0.21 | 0.150 | na | 0.29 | 0.043 |
| IgG score: | ||||||||||||||||
| Negative | 10.1 (3.4–10.8) | na | 0.474 | 1.2 (0.2–3.7) | na | 0.490 | 1.0 (0.6–4.8) | na | 0.979 | 0.1 (0.0 – 0.5) | na | 0.343 | 0.2 (0.0 – 0.5) | na | 0.166 | |
| Positive | 10.9 (1.1–12.1) | 0.5 (0.2–2.2) | 1.4 (0.2–4.6) | 0.3 (0.0–1.2) | 0.3 (0.0–1.4) | |||||||||||
| IgM index | na | 0.14 | 0.360 | na | 0.05 | 0.738 | na | 0.06 | 0.711 | na | 0.15 | 0.306 | na | 0.11 | 0.461 | |
| IgM score: | ||||||||||||||||
| Negative | 10.3 (0.8–12.0) | na | 0.445 | 1.0 (0.2–3.3) | na | 0.533 | 1.2 (0.2–7.5) | na | 0.855 | 0.2 (0.0–1.1) | na | 0.763 | 0.3 (0.0 – 0.6) | na | 0.714 | |
| Positive | 10.9 (1.5–12.1) | 0.4 (0.1–2.2) | 1.3 (0.3–4.0) | 0.2 (0.0–1.2) | 0.2 (0.0–1.4) | |||||||||||
| IgG+/IgM+ | 10.9 (1.5–12.1) | na | 0.781 | 0.5 (0.3–2.2) | na | 0.339 | 1.4 (0.5–4.0) | na | 0.626 | 0.3 (0.0–1.2) | na | 0.435 | 0.2 (0.0–1.4) | na | 0.395 | |
| IgG+/IgM− | 9.1 (0.8–12.0) | 0.6 (0.1–2.1) | 1.3 (0.1–7.5) | 0.3 (0.0–1.7) | 0.4 (0.0–1.3) | |||||||||||
| IgG−/IgM+b | 3.8 | 0.0 | 0.0 | 0 | 0 | |||||||||||
| IgG−/IgM− | 10.3 (1.7–11.5) | 1.6 (0.7–4.6) | 1.2 (0.7–7.2) | 0.2 (0.0–1.1) | 0.2 (0.0 – 0.5) | |||||||||||
Mann–Whitney or Kruskal–Wallis test for categorical variables; Spearman’s correlation for continuous variables; rs: Spearman’s correlation coefficient; na: not applicable.
+ and − are related to the IgG and/or IgM scores.
a
Missing values: days from symptom onset, 4; severity of disease, 1.
b
IgG−/IgM+ there was one patient.