Table 2.
Individual data of the adrenalectomy group showing the results from immunohistochemical analysis, histological size of an APA, adrenal venous sampling (AVS), 11C-metomidate (11C-MTO) positron emission tomography (PET), and biochemical and clinical improvement according to (19).
| Histology based on CYP11B2 | APA size, mm | Operation side | APCC, n | AVS, LI | AVS, side | SUVmax Right | SUVmax Left | SUVmax ratio | PET, side | PET finding | AVS vs PET | Biochemical improvement | Clinical improvement |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| APA | 13 | Left | 1 | 159.9 | L | 6.7 | 25.8 | 3.38 | L | Adenoma | Concordant | Complete | Partial |
| APA | 12 | Left | 2 | NA | NA | 8.8 | 20 | 2.28 | L | Adenoma | NA | Complete | Complete |
| APA | 15 | Left | 0 | 23.4 | L | 9 | 19.6 | 2.19 | L | Adenoma | Concordant | Complete | Complete |
| APA | 14 | Left | 1 | 59.5 | L | 23.2 | 47.8 | 2.06 | L | Adenoma | Concordant | Complete | Complete |
| APA | 14 | Left | 0 | 151.8 | L | 11 | 21.7 | 1.98 | L | Adenoma | Concordant | Complete | Partial |
| Non-APA | - | Right | 4 | 34.7 | R | 46.4 | 23.6 | 1.97 | R | Adenoma | Concordant | Absent* | Partial |
| Non-APA | - | Right | 5 | NA | NA | 25.7 | 13.5 | 1.9 | R | Adenoma | NA | Complete | Partial |
| APA | 29 | Right | 1 | 105.5 | R | 37.9 | 21.5 | 1.76 | R | Adenoma | Concordant | Complete | Partial |
| Non-APA | - | Left | 2 | 7.2 | L | 9.2 | 16.2 | 1.66 | L | Adenoma | Concordant | Complete | Absent# |
| APA | 7 | Left | 0 | NA | NA | 14.1 | 22.2 | 1.57 | L | Hyperplasia L | NA | Complete | Absent# |
| Non-APA | - | Right | 4 | 3 | R | 17.1 | 11.1 | 1.54 | R | Hyperplasia R | Concordant | Complete | Partial |
| Non-APA | - | Left | 5 | 5.3 | L | 13.8 | 20.6 | 1.49 | L | Adenoma | Concordant | Complete | Partial |
| Non-APA | - | Left | 0 | 5.2 | L | 12.7 | 17.7 | 1.39 | L | Hyperplasia L | Concordant | Partial | Partial |
| APA | 16 | Left | 0 | 66.4 | L | 20.9 | 28.9 | 1.38 | L | Adenoma | Concordant | Complete | Complete |
| APA | 10 | Right | 1 | 128.9 | R | 26.3 | 19.3 | 1.36 | R | Adenoma | Concordant | Complete | Partial |
| APA | 13 | Right | 0 | 54.2 | R | 17.7 | 24 | 1.36 | L | Hyperplasia L | Discordant | Not done | Partial* |
| APA | 8 | Right | 3 | 13.3 | R | 22.6 | 17.4 | 1.3 | R | Adenoma (suspicion) | Concordant | Complete | Partial |
| APA | 13 | Right | 2 | 29.2 | R | 17.4 | 13.9 | 1.25 | R | Adenoma | Concordant | Complete | Complete |
| APA | 12 | Left | 0 | 14.2 | L | 42.1 | 34 | 1.24 | R | Adenoma R/Hyperplasia L | Discordant | Not done | Partial* |
| APA | 7 | Right | 1 | NA | NA | 28.7 | 34.2 | 1.19 | L | Adenoma L/ Hyperplasia R |
NA | Partial | Partial |
| APA | - | Left | 2 | 19.6 | L | 25.6 | 30.3 | 1.18 | L | Adenoma | Concordant | Complete | Complete |
| Non-APA | - | Left | 5 | 36.6 | L | 20.6 | 24 | 1.17 | L | Hyperplasia L | Concordant | Complete | Complete |
| APA | 14 | Left | 4 | 8.4 | L | 29.2 | 33.5 | 1.15 | None | No activity difference | Discordant | Complete | Complete |
| APA | 15 | Right | 0 | 6.3 | R | 51.4 | 44.7 | 1.15 | None | Hyperplasia both sides | Discordant | Partial | Partial |
| APA | 18 | Left | 2 | 4.8 | L | 18.5 | 20 | 1.08 | None | Hyperplasia both sides | Discordant | Complete | Complete |
| Non-APA | - | Left | 5 | 10.7 | L | 36.5 | 39.1 | 1.07 | None | No activity difference | Discordant | Partial | Partial |
| Non-APA | - | Right | 8 | 5.9 | R | 15.4 | 14.5 | 1.06 | None | No activity difference | Discordant | Complete | Complete |
| APA | - | Left | 3 | 9 | L | 29.4 | 28.3 | 1.04 | None | No activity difference | Discordant | Complete | Partial |
| Non-APA | - | Right | 4 | 13 | R | 20.1 | 19.4 | 1.04 | None | No activity difference | Discordant | Complete | Complete |
| APA | 20 | Left | 1 | 95.6 | L | 20.4 | 21.1 | 1.03 | None | No activity difference | Discordant | Complete | Partial |
| APA | 12 | Left | 4 | 88.5 | L | 31.2 | 32.2 | 1.03 | None | Hyperplasia both sides | Discordant | Complete | Complete |
| Non-APA | - | Right | 5 | 8.1 | R | 23.5 | 24.3 | 1.03 | None | No activity difference | Discordant | Complete | Partial |
| APA | 9 | Left | 2 | 4.3 | L | 34.8 | 34.9 | 1 | None | Hyperplasia both sides | Discordant | Partial | Partial |
| APA | 14 | Right | 0 | 132.5 | R | NA | NA | NA | NA | NA | NA | Complete | Partial |
Data are organized according to descending SUVmax-ratios.
*
Subjects with contralateral findings in AVS and 11C-MTO-PET.
#
Subjects with absent clinical or biochemical improvement by PASO criteria (ref. (19)) all showed improvement that did not meet the criteria.
AVS, adrenal venous sampling; L, left; LI, lateralization index; NA, not applicable; R, right; SUV, standardized uptake value.