Table 1.
Characteristics of cases and their matched controls
| Controls N = 169 | Cases N = 169 | |
|---|---|---|
| Male, % | 100 | 100 |
| Age at first positive HBV test, mean (yrs) | 52.0 | 52.2 |
| Age at index date, mean (yrs) | 59.9 | 60.3 |
| Year of first positive HBV test, % | ||
| 1999–2001 | 29.6 | 29.6 |
| 2001–2003 | 45.6 | 45.6 |
| 2004–2006 | 17.2 | 17.2 |
| 2007–2011 | 7.7 | 7.7 |
| Time interval between first positive HBV test and index date, yrs | 8.0 | 8.1 |
| Index Date Year, % | ||
| 2004–2007 | 18.3 | 18.3 |
| 2008–2010 | 33.1 | 33.1 |
| 2011–2013 | 34.9 | 34.9 |
| 2014–2017 | 13.6 | 13.6 |
| Race/Ethnicity, % | ||
| White, non-Hispanic | 46.2 | 44.4 |
| Black, non-Hispanic | 39.1 | 34.9 |
| Other | 14.8 | 20.7 |
| Cirrhosis, % | 36.7 | 36.7 |
| HBeAg positive, % | 36.7% | 40.1% |
| Maximum HBV DNA viral load 5 years prior to index date ≥ 2000 (e Ag negative) or ≥ 20,000 (e Ag positive) | 46.2 | 53.8 |
| HBV antiviral treatment, % | 46.2 | 46.2 |
| Facility complexity,% | ||
| Ambulatory (Basic or Advanced) | 3.7 | 5.1 |
| Inpatient Standard | 3.7 | 2.6 |
| Inpatient Intermediate | 13.5 | 14.1 |
| Inpatient Complex | 79.1 | 78.2 |
| BMI, mean (Kg/m2) | 27.9 | 27.1 |
| Diabetes, % | 23.7 | 28.4 |
| Alcohol Use Disorders, % | 36.7 | 42 |
| HIV Coinfection, % | 13.0 | 14.2 |
| CT or MRI before index date, % | ||
| 0–2 years | 29.6 | 21.3 |
| 0–3 years | 37.9 | 25.4 |
| 0–4 years | 44.4 | 27.2 |
Abbreviations: HBV – hepatitis B virus, HBeAg – hepatitis B e antigen, HBV DNA – hepatitis B viral load, BMI – body mass index, HIV – human immunodeficiency virus, CT – computed tomography, MRI – magnetic resonance imaging