Table 1.
Baseline Characteristics of Participants with a Serious Adverse Event for Syncope, Hypotension, or Fall
| Baseline Characteristica | Syncope | Hypotension | Falls | |||
|---|---|---|---|---|---|---|
| HRb (95% CI) | P-valuec | HRb (95% CI) | P-valuec | HRb (95% CI) | P-valuec | |
| Age, years | 1.51 (1.30,1.76) | <0.01 | 1.26 (1.07,1.47) | 0.004 | 3.00 (2.57,3.50) | <0.001 |
| Age Class, years | ||||||
| 50 to 74 | REF | <0.001 | REF | 0.2 | REF | <0.001 |
| 75 to 84 | 1.92 (1.39,2.66) | 1.37 (0.96,1.94) | 4.59 (3.34,6.32) | |||
| 85 or older | 2.88 (1.65,5.05) | 1.31 (0.61,2.81) | 15.53 (10.66,22.63) | |||
| Intensive Treatment Group | 1.32 (0.98,1.79) | 0.07 | 1.67 (1.21,2.32) | 0.002 | 0.98 (0.75,1.29) | 0.9 |
| Women | 1.13 (0.83,1.53) | 0.45 | 0.75 (0.53,1.07) | 0.11 | 1.56 (1.18,2.05) | 0.002 |
| Race/Ethnicity | ||||||
| White | REF | 0.073 | REF | 0.017 | REF | <0.001 |
| Black | 0.89 (0.64,1.25) | 0.83 (0.59,1.19) | 0.35 (0.24,0.52) | |||
| Other | 0.50 (0.28,0.91) | 0.36 (0.18,0.74) | 0.37 (0.21,0.65) | |||
| CVD History | 1.29 (0.91,1.83) | 0.16 | 2.01 (1.44,2.81) | <0.001 | 1.58 (1.16,2.15) | 0.004 |
| CKD - Stage 3 or 4 | 1.49 (1.09,2.03) | 0.012 | 2.03 (1.48,2.79) | <0.001 | 2.13 (1.61,2.81) | <0.001 |
| Orthostatic Hypotension | 1.20 (0.7,2.03) | 0.51 | 1.58 (0.96,2.62) | 0.075 | 1.77 (1.17,2.7) | 0.007 |
| Dizzy on Standing | 1.01 (0.47,2.14) | 0.99 | 1.62 (0.85,3.08) | 0.14 | 0.97 (0.48,1.97) | 0.93 |
| BMI Categories | ||||||
| Normal weight | REF | 0.003 | REF | 0.19 | REF | <0.001 |
| Over weight | 0.60 (0.41,0.87) | 0.7 (0.46,1.06) | 0.57 (0.41,0.79) | |||
| Obese | 0.54 (0.37,0.79) | 0.72 (0.48,1.08) | 0.37 (0.26,0.52) | |||
| # of BP Meds | ||||||
| none | REF | 0.15 | REF | 0.007 | REF | 0.41 |
| 1 or 2 | 1.73 (0.87,3.4) | 1.42 (0.71,2.81) | 1.3 (0.75,2.26) | |||
| 3 or more | 2.01 (0.99,4.08) | 2.26 (1.12,4.57) | 1.47 (0.82,2.63) | |||
| Poor BP Med Adherence | 0.60 (0.39,0.95) | 0.028 | 0.48 (0.28,0.8) | 0.005 | 0.58 (0.38,0.89) | 0.012 |
| Beta-blocker Use | 1.30 (0.96,1.78) | 0.093 | 1.5 (1.09,2.07) | 0.013 | 1.6 (1.21,2.11) | 0.001 |
| Nitrate Use | 2.40 (1.33,4.31) | 0.004 | 3.92 (2.37,6.48) | <0.001 | 1.66 (0.88,3.13) | 0.12 |
| Alpha blocker Use | 1.77 (1.01,3.12) | 0.048 | 1.31 (0.67,2.58) | 0.43 | 1.99 (1.21,3.27) | 0.007 |
| Frail | 1.45 (1.06,1.98) | 0.021 | 2.47 (1.8,3.39) | <0.001 | 2.39 (1.81,3.16) | <0.001 |
| Systolic Blood Pressure, mmHg | 1.03 (0.88,1.19) | 0.73 | 0.97 (0.82,1.13) | 0.68 | 1.15 (1,1.31) | 0.043 |
| Gait speedd, m/s | 1.13 (0.9,1.42) | 0.3 | 0.91 (0.68,1.21) | 0.53 | 0.72 (0.61,0.87) | <0.001 |
CVD= cardiovascular disease, CKD= chronic kidney disease, BMI= body mass index, BP= blood pressure
a
for additional baseline characteristics, see supplemental table online
b
Hazard Ratios are relative to reference category for categorical variables and per standard deviation unit for continuous variables
c
P-values are for tests of any difference among categories
d
Assessed only for participants ≥75 years of age