Table 2.

Age and treatment group vs. time until first syncope, hypotension and fall SAE.

	Syncope		Hypotension		Falls
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Categorical Age
Model 1a
Age <75	REF	<.001	REF	.36	REF	<.001
Age 75 – 84	1.85 (1.33,2.58)		1.29 (0.90,1.84)		3.95 (2.85,5.47)
Age 85+	2.78 (1.58,4.91)		1.27 (0.59,2.74)		12.88 (8.76,18.95)
Standard Therapy	REF	.061	REF	.002	REF	.98
Intensive Therapy	1.33 (0.99,1.80)		1.68 (1.22,2.33)		1.00 (0.76,1.31)
Rx by Age Interaction		.35		.72		.75
Model 2b
Age <75	REF	.002	REF	.42	REF	<.001
Age 75 – 84	1.74 (1.22,2.47)		1.00 (0.68,1.47)		3.32 (2.33,4.72)
Age 85+	2.34 (1.27,4.33)		0.51 (0.18,1.41)		9.04 (5.81,14.07)
Standard Therapy	REF	.21	REF	.005	REF	.73
Intensive Therapy	1.22 (0.89,1.66)		1.63 (1.16,2.28)		0.95 (0.71,1.27)
Rx by Age Interaction		.43		.53		.45
Model 3c
Age <75	REF	.003	REF	.62	REF	<.001
Age 75 – 84	1.72 (1.19,2.48)		1.00 (0.67,1.49)		3.12 (2.17,4.50)
Age 85+	2.32 (1.22,4.43)		0.60 (0.22,1.69)		8.44 (5.28,13.49)
Standard Therapy	REF	.44	REF	.011	REF	.76
Intensive Therapy	1.14 (0.82,1.56)		1.57 (1.11,2.23)		1.05 (0.77,1.42)
Rx by Age Interaction		.48		.66		.57
Continuous Age
Model 1a
Aged	1.50 (1.28,1.76)	<0.001	1.24 (1.05,1.46)	0.011	2.83 (2.41,3.3)	<0.001
Standard Therapy	REF	0.050	REF	0.002	REF	0.98
Intensive Therapy	1.34 (0.99,1.81)		1.68 (1.22,2.33)		1.00 (0.76,1.31)
Rx by Age Interaction		0.80		0.62		0.29
Model 2b
Aged	1.45 (1.22,1.72)	<0.001	1.05 (0.87,1.26)	0.64	2.46 (2.05,2.94)	<0.001
Standard Therapy	REF	0.21	REF	0.005	REF
Intensive Therapy	1.22 (0.90,1.66)		1.63 (1.16,2.28)		0.95 (0.71,1.27)	0.74
Rx by Age Interaction		0.72		0.90		0.091
Model 3c
Aged	1.43 (1.19,1.72)	<0.001	1.04 (0.86,1.28)	0.67	2.36 (1.96,2.85)	<0.001
Standard Therapy	REF	0.44	REF	0.012	REF	0.74
Intensive Therapy	1.13 (0.82,1.56)		1.57 (1.10,2.22)		1.05 (0.78,1.42)
Rx by Age Interaction		0.62		0.52		0.13

^aModel 1 (N=9344) includes age, treatment group and demographic factors (sex, race and education).

^bModel 2 (N=8778) includes age, treatment group, demographic factors and health conditions (cardiovascular disease history, chronic kidney disease, BMI category, alcohol use, being frail).

^cModel 3 (N=7872) includes age, treatment group, demographic factors, health conditions and baseline measurements (systolic blood pressure, heart rate, orthostatic hypotension, dizziness, number of BP medications and use of beta blockers, diuretics, ace inhibitors, angiotensin II receptor blockers, calcium channel blockers, alpha blockers, nitrates and digoxin).

^dAge as a continuous variable. HRs for age are for each 1 SD of age (9.4 years)