Table 2.
Linear model shows reduced cnLOH affected chromosomes in African Americans after adjustment for covariates. (1) All African American and White complete cases from TCGA and CCCC, (2) African American complete cases from TCGA and CCCC, (3) White complete cases from TCGA
Dependent variable: | |||
---|---|---|---|
Number of arms affected by cnLOH | |||
(1) | (2) | (3) | |
Age (years) | 0.005 (−0.049, 0.060) | −0.012 (−0.061, 0.037) | 0.019 (−0.067, 0.105) |
African American Race | −3.022*** (−4.668, −1.375) | ||
Underweight BMI | 1.322 (−5.781, 8.425) | 0.539 (−3.648, 4.726) | |
Overweight BMI | 0.086 (−1.399, 1.572) | 1.192 (−0.254, 2.638) | −1.157 (−3.467, 1.154) |
Obese BMI | 0.171 (−1.356, 1.698) | 0.816 (−0.538, 2.171) | −0.131 (−2.522, 2.260) |
Tumor Stage II | 0.679 (−1.247, 2.605) | 2.007** (0.287, 3.727) | −0.443 (−3.536, 2.650) |
Tumor Stage III | 1.093 (−0.787, 2.974) | 0.125 (−1.515, 1.766) | 1.574 (−1.436, 4.585) |
Tumor Stage IV | 1.508 (−0.652, 3.669) | 0.439 (−1.383, 2.260) | 2.299 (−1.362, 5.960) |
TCGA Cohort | 0.828 (−1.042, 2.698) | 0.968* (−0.140, 2.076) | |
Male Gender | −0.184 (−1.449, 1.081) | −0.195 (−1.390, 0.999) | 0.420 (−1.588, 2.429) |
Intercept | 2.881 (−1.428, 7.189) | 0.416 (−3.027, 3.859) | 3.123 (−3.058, 9.305) |
Observations | 135 | 58 | 77 |
p<0.1;
p<0.05;
p<0.001