Table 2.
Univariate and multivariate analysis of predictive variables for ctDNA concentration in early-stage and all cases
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
| n | Regression coefficient | P | Regression coefficient | P | |
| Early stage | 153 | ||||
| Age (≥50 y) | 19 | −16.5 | .008* | −1.3 | .92 |
| ESR (≥30 or ≥50 w/o B symptoms) | 73 | 22 | .05* | 20.4 | .006* |
| MT (≥0.35) | 66 | 13.2 | .09 | ||
| Extranodal disease (present) | 1 | −12 | .79 | ||
| Nodal regions (≥4) | 49 | 25.3 | .001* | 23.8 | .002* |
| Sex (male) | 64 | 19.7 | .007* | 21.8 | .003* |
| Advanced stage† | 23 | ||||
| Hemoglobin (<10.5 g/dL) | 5 | 1.4 | .70 | ||
| Sex (male) | 15 | 2.1 | .51 | ||
| Stage (IV) | 14 | −1.3 | .68 | ||
| Age (≥45 y) | 5 | 2.5 | .49 | ||
| White blood cell count (≥15 × 109/L) | 5 | 0.4 | .91 | ||
| Lymphocyte count (≤ 0.6 × 109/L) | 23 | NA | NA | ||
NA, not available; w/o, without.
*
Significant.
†
No data were available on serum albumin levels.