Table 3.

Risk of disease progression/relapse according to PET/CT and cfDNA results after 2 cycles of chemotherapy in patients with CNAs at diagnosis (N = 164)

	cfDNA result*
	Positive		Negative		Not available		Total, n
	n†	Therapy failure‡	n†	Therapy failure‡	n†	Therapy failure‡
PET/CT
Positive	8	3 (38)	14	3 (21)	7	2 (29)	29
Negative	16	2 (13)	70	1 (1)	27	2 (7)	113
Not available	2	1 (50)	12	1 (8)	8	0 (0)	22
Total	26	6 (22)	96	5 (5)	42	4 (9)	164

^*Positive cfDNA, profiles with persistent aberrations or with new aberrations confirmed by duplicate analysis; not available, cases with no plasma sample at C3D1 or with equivocal cfDNA profiles.

^†The number of cases according to PET and/or cfDNA status after 2 cycles.

^‡The number (proportion) of cases with therapy failure is shown according to PET and/or cfDNA status after 2 cycles. Therapy failure is defined as lack of complete remission at end of therapy or relapse after end of therapy.