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Hemin binds directly to both CLEC-2 and GPVI. Direct binding of hemin to immobilized human CLEC-2 (left) and human GPVI (right) evaluated by using the BIAcore X system. The changes in RU using different concentrations of hemin (0, 0.1, 0.5, and 1.0 μg/mL) are shown.
