Table 1.
Characteristics of patients at hypoglycemia onset
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
|---|---|---|---|---|---|
| Age, y | 80 | 24 | 72 | 72 | 55 |
| Sex | Male | Male | Male | Male | Male |
| Date of hypoglycemia diagnosis | 2015 | 2000 | 2012 | 2017 | 2018 |
| MCD, y since diagnosis | 3 | 4 | 0 | 8 | 0 |
| Clinical presentation | Fever | Splenomegaly | Fever | Splenomegaly | Splenomegaly |
| Adenopathy | Adenopathy | Adenopathy | Adenopathy | Adenopathy | |
| Coma | |||||
| CRP, mg/L | 117 | 5 | 200 | 50 | 37 |
| IL-6, pg/mL | NA | 31.9 | NA | NA | 33 |
| Gammaglobulin, g/L | 58.9 | 20.8 | 18.4 | 34 | 65 |
| KS, at diagnosis | No | No | Yes | No | No |
| HHV8 RT-PCR (log) | 5.8 | 4.78 | +* | +* | 6.29 |
| HIV, y since diagnosis | † | 14 | † | 12 | † |
| CD4, mm−3 | † | 330 | † | 432 | † |
| HIV viral load, copies per mL | † | 2210 | † | 47 | † |
| Glycemia, mmol/L | 2.0 | 2.3 | 2.05 | 1.6 | 3.4 |
| Insulin, mIU/L | 2.84 | 4.1 | 290 | 242 | NA |
| C-peptide, nmol/L | <0.10 | <0.10 | 1.491 | 3.3 | NA |
| Anti-IR Ab | Yes | Yes | Yes | Yes | Yes |
| Inhibition of insulin binding | Yes | Yes | Yes | Yes | Yes |
| Anti-insulin Ab | No | No | No | No | No |
| Other immune manifestations | No | No | No | wAIHA | wAIHA, lupus anticoagulant |
Ab, antibody; KS, Kaposi sarcoma; NA, not available; RT-PCR, real-time polymerase chain reaction; wAIHA, warm autoimmune hemolytic anemia.
*
HHV8 qualitative evaluation.
†
Not appropriate (HIV−).