Table 2.
Frequency of histological alterations identified in the liver and kidney of rats treated with CGA and TAM for 14 consecutivedays
| Parameters | Control | TAM alone | CGA alone | TAM + CGA1 | TAM + CGA2 |
|---|---|---|---|---|---|
| Liver | |||||
| Congestion of vessels | 0 | 3 | 0 | 2 | 1 |
| Focal area of inflammation | 0 | 4 | 0 | 2 | 1 |
| Fatty infiltration | 0 | 4 | 0 | 1 | 1 |
| Kidney | |||||
| Large vacuoles | 0 | 3 | 0 | 2 | 1 |
| Focal area of necrosis | 0 | 4 | 0 | 1 | 1 |
| Inflammatory cells | 0 | 4 | 0 | 1 | 1 |
| Hepatic degeneration | 0 | 4 | 0 | 2 | 1 |
Chlorogenic acid -CGA: 25 and 50 mg/kg; Tamoxifen -TAM: 50 mg/kg n = 10. Values are indicative of the severity of histological changes observed in their tissues. Scores: 0—within normal limit; 1—change barely exceed that within normal limit; 2—easily identified lesion with limited severity; 3—prominent lesions with potential for severity; 4—complete severe changes as possible in organ.