Figure 3 .

Effects of DIOB on major metabolic pathways in the mouse lung and plasma. (A) Metabolic pathways of lung mainly affected by DIOB: a. taurine and hypotaurine metabolism, b. sphingolipid metabolism, c. valine, leucine, and isoleucine biosynthesis, d. arachidonic acid metabolism, e. nicotinate and nicotinamide metabolism, f. histidine metabolism, g. glycerophospholipid metabolism, h. alanine, aspartate, and glutamate metabolism, and i. arginine and proline metabolism. (B) Metabolic pathways of plasma mainly affected by DIOB: 1. linoleic acid metabolism, 2. valine, leucine, and isoleucine biosynthesis, 3. arachidonic acid metabolism, 4. glycerophospholipid metabolism, 5. arginine and proline metabolism, and 6. tryptophan metabolism.