Table 3.
The average change of main metabolites (VIP value >1) in lung (mean ± SD)
| No. | Metabolites | % Average changes, 10 mg/kg | % Average changes, 30 mg/kg | % Average changes, 60 mg/kg |
|---|---|---|---|---|
| 1 | PC[20:1(11Z)/14:1(9Z)] | 122.41 ± 23.14↑ | 112.74 ± 18.67↑ | 156.54 ± 31.14↑ |
| 2 | PC[16:1(9Z)/20:3(8Z,11Z,14Z)] | 64.42 ± 6.08↓ | 59.09 ± 6.84↓ | 53.87 ± 7.63↓ |
| 3 | SM[d18:0/16:1(9Z)] | 83.39 ± 11.81↓ | 96.84 ± 8.72↓ | 65.34 ± 10.92↓ |
| 4 | PC[18:0/20:4(8Z,11Z,14Z,17Z)] | 64.99 ± 15.42↓ | 73.68 ± 7.40↓ | 48.20 ± 9.17↓ |
| 5 | Phytosphingosine | 87.01 ± 20.70↓ | 50.35 ± 12.61↓ | 45.33 ± 7.77↓ |
| 6 | PC[14:1(9Z)/20:0] | 105.88 ± 25.26↑ | 120.00 ± 8.23↑ | 80.19 ± 13.99↓ |
| 7 | Lactic acid | 214.69 ± 63.81↑ | 173.45 ± 31.15↑ | 201.44 ± 40.37↑ |
| 8 | Histamine | 63.62 ± 8.03↓ | 46.91 ± 5.58↓ | 46.93 ± 10.11↓ |
| 9 | LysoPC(18:0) | 162.99 ± 29.53↑ | 100.79 ± 17.50↑ | 170.53 ± 43.44↑ |
| 10 | LysoPC[18:1(11Z)] | 207.14 ± 40.64↑ | 156.08 ± 34.80↑ | 231.09 ± 43.5↑ |
| 11 | SM(d18:1/16:0) | 86.83 ± 7.70↓ | 96.01 ± 8.85↓ | 69.04 ± 14.51↓ |
| 12 | Docosahexaenoic acid | 143.97 ± 39.01↑ | 161.16 ± 28.44↑ | 218.9 ± 63.45↑ |
| 13 | SM[d18:0/24:1(15Z)] | 317.71 ± 18.79↑ | 352.37 ± 67.38↑ | 296.53 ± 70.23↑ |
| 14 | PC(14:0/P-18:0) | 217.20 ± 61.90↓ | 176.48 ± 10.32↑ | 243.88 ± 60.32↑ |
| 15 | LysoPC[16:1(9Z)] | 227.78 ± 61.45↑ | 160.84 ± 44.37↑ | 196.67 ± 39.64↑ |
| 16 | LysoPC[18:2(9Z,12Z)] | 229.44 ± 50.97↑ | 135.62 ± 41.88↑ | 198.96 ± 66.93↑ |
| 17 | PG(18:0/16:0) | 89.65 ± 5.43↓ | 102.6 ± 29.15↑ | 200.59 ± 50.93↑ |
| 18 | PC[o-16:1(9Z)/20:4(8Z,11Z,14Z,17Z)] | 64.83 ± 15.27↓ | 60.2 ± 19.12↓ | 52.64 ± 13.87↓ |
| 19 | PC[18:1(9Z)/20:4(5Z,8Z,11Z,14Z)] | 76.35 ± 8.96↓ | 67.00 ± 8.35↓ | 63.71 ± 12.35↓ |
| 20 | PC[16:1(9Z)/22:2(13Z,16Z)] | 127.84 ± 33.44↑ | 73.50 ± 11.90↓ | 64.90 ± 8.60↓ |
| 21 | l-carnitine | 109.61 ± 8.39↑ | 119.20 ± 16.59↑ | 118.33 ± 14.12↑ |
| 22 | SM(d18:1/24:0) | 428.84 ± 28.16↑ | 413.41 ± 31.87↑ | 407.33 ± 90.98↑ |
| 23 | Propenoylcarnitine | 21.38 ± 4.56↓ | 2.76 ± 0.72↓ | 2.54 ± 0.89↓ |
| 24 | Sphinganine | 46.56 ± 12.36↑ | 86.41 ± 17.83↓ | 109.88 ± 22.21↑ |
| 25 | Arachidonic acid | 164.56 ± 35.14↑ | 90.72 ± 22.16↓ | 125.84 ± 33.24↑ |
| 26 | PC[20:3(5Z,8Z,11Z)/14:1(9Z)] | 162.39 ± 30.84↑ | 185.99 ± 30.45↑ | 154.29 ± 43.61↑ |
| 27 | LysoPC[20:4(8Z,11Z,14Z,17Z)] | 133.35 ± 26.42↑ | 112.65 ± 36.49↑ | 161.52 ± 39.55↑ |
| 28 | PC[16:1(9Z)/22:5(7Z,10Z,13Z,16Z,19Z)] | 84.05 ± 19.04↓ | 66.84 ± 9.92↓ | 78.33 ± 15.94↓ |
| 29 | 12-HETE | 74.98 ± 1.66↓ | 76.80 ± 17.64↓ | 128.13 ± 32.8↑ |
| 30 | LysoPC(14:0) | 249.72 ± 68.53↑ | 206.31 ± 52.14↑ | 317.53 ± 89.88↑ |
| 31 | Niacinamide | 146.58 ± 37.05↑ | 120.25 ± 12.88↑ | 124.45 ± 22.07↑ |
| 32 | N-methyl-d-aspartic acid | 89.67 ± 13.89↓ | 106.14 ± 26.89↑ | 119.7 ± 18.55↑ |
| 33 | l-acetylcarnitine | 112.43 ± 26.22↑ | 109.93 ± 17.26↑ | 127.89 ± 31.78↑ |
| 34 | Taurine | 115.61 ± 18.47↑ | 121.90 ± 12.61↑ | 119.81 ± 6.15↑ |
| 35 | l-leucine | 92.93 ± 13.64↓ | 90.38 ± 13.83↓ | 91.68 ± 16.80↓ |
| 36 | LysoPC(17:0) | 180.87 ± 25.70↑ | 118.86 ± 24.62↑ | 186.41 ± 43.12↑ |
| 37 | SM(d18:1/22:0) | 209.1 ± 39.69↑ | 191.68 ± 40.37↑ | 156.75 ± 37.87↑ |
| 38 | PC[20:0/20:4(5Z,8Z,11Z,14Z)] | 291.73 ± 76.84↑ | 204.73 ± 35.84↑ | 273.71 ± 63.40↑ |
| 39 | l-arginine | 71.37 ± 12.83↓ | 66.17 ± 12.53↓ | 63.50 ± 14.41↓ |
| 40 | Neuraminic acid | 80.06 ± 20.59↓ | 155.99 ± 41.13↑ | 133.34 ± 30.80↑ |
| 41 | PC[o-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)] | 58.49 ± 10.57↓ | 64.31 ± 7.79↓ | 63.01 ± 4.35↓ |
| 42 | Cer[d18:1/24:1(15Z)] | 119.42 ± 27.98↑ | 22.21 ± 2.15↓ | 28.86 ± 3.86↓ |
Arrow indicates significantly up-regulated or down-regulated metabolites in the DIOB different dose groups compared with the control.