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. 2021 Mar 9;217(3):iyab004. doi: 10.1093/genetics/iyab004

Table 2.

GPCR and odorant pairings

GPCR Chemical Ligand Neurons functioning in Behavior Reference(s)
ODR-10 Diacetyl (low) AWA Attraction

(Sengupta et al. 1996)

(Zhang et al. 1997)

STR-2 2-Heptanone AWCON Attraction (Zhang et al. 2016)
DCAR-1

Dihydrocaffeic acid

Benzaldehyde ? (undiluted)

ASH Avoidance (Aoki et al. 2011)
SRI-14 Diacetyl (high) ASH Avoidance (Taniguchi et al. 2014)
SRB-6

Dodecanoic acid

Decanoic acid?

ASH, ADL, ADF (head)a

PHA, PHB (tail)

Avoidance (Tran et al. 2017)
STR-217 DEET ADL “Confusant” (Dennis et al. 2018)

The limited number of C. elegans chemosensory GPCRs that have been paired with odorant ligands are shown.

a

SRB-6 rescued anterior response when expressed in these three head neurons, but promoters with more restrictive expression patterns were not used (Tran et al. 2017).