Table 2.
Types of GRNs in taste hairs
| Sensilla | # GRNs | GRN | Markers | Former GRN names | Activators | Suppressors |
|---|---|---|---|---|---|---|
| S-type | 4 | |||||
| A | Gr64f | “Sweet” | Sugars, low Na+, glycerol, fatty acids, acetic acida | Bitter, Ca2+, acids | ||
| Bb | Gr66a | “Bitter” | Bitter, high Na+, acids, polyamines, tryptophan, L-canavanine, cool temperatures | |||
| C | Ppk28 | “Water” | H2O (hypo-osmolarity) | Osmolytes, salts (e.g. Na+) | ||
| Dsc | Ppk23, VGlut | “Cation” | High cations (e.g. Ca2+, Na+, K+) | |||
| I-type | 2 | |||||
| A | Gr64f | “Sweet” | Sugars, low Na+, glycerol, fatty acids, acetic acida | Bitter, Ca2+, acids | ||
| B | Gr66a | “Bitter” | Bitter, acids, cool temperatures | |||
| L-type | 4 | |||||
| A | Gr64f | “Sweet” | Sugars, low Na+, glycerol, acetic acida | Bitter, Ca2+, acids | ||
| C | Ppk28 | “Water” | H2O (hypo-osmolarity) | Osmolytes, salts (e.g. Na+) | ||
| DL | Ppk23, VGlut | “Cation” | High cations (e.g. Na+, K+) | |||
| E | Ir94e | “Low salt” | Low Na+ |
A GRNs are more responsive to acetic acid in starved flies.
A subset of these B neurons are also positive for Ppk23 and ChAT.
These GRNs respond non-selectively to cations with particularly strong responses to Ca2+.