Table 1.
Localization and origin of NCO events
| NCO localization |
DMC1 coloc.a |
NCO localization |
DMC1 coloc.a |
|||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr | Start | End | Minb | Maxb | B6 | (PWD× B6)F1 | PWD | B6. Prdm9−/− | Non parentalc | Chr | Start | End | Minb | Maxb | B6 | (PWD× B6)F1 | PWD | B6. Prdm9−/− | Non parentalc | |||
| 1 | 13845860 | 13845929 | 70 | 277 | T | T | F | F | F | 4 | 92481179 | 92481179 | 1 | 596 | F | F | F | F | NA | |||
| 1 | 46907980 | 46907980 | 1 | 419 | T | T | F | F | F | 4 | 125451332 | 125451332 | 1 | 661 | T | T | F | F | F | |||
| 1 | 59359320 | 59359321 | 2 | 692 | T | T | F | F | F | 4 | 142990293 | 142990308 | 16 | 364 | T | T | F | F | F | |||
| 1 | 61872329 | 61872329 | 1 | 69 | T | T | F | F | F | 5 | 6242093 | 6242323 | 231 | 407 | T | T | F | F | F | |||
| 1 | 63879266 | 63879271 | 6 | 117 | F | T | F | F | T | 5 | 20789067 | 20789067 | 1 | 115 | T | T | F | F | F | |||
| 1 | 67960742 | 67963400 | 2659 | 3994 | T | T | F | F | F | 5 | 27852657 | 27852657 | 1 | 338 | T | T | F | F | F | |||
| 1 | 128517316 | 128517318 | 3 | 985 | T | T | F | F | F | 5 | 51691842 | 51691842 | 1 | 92 | T | T | F | F | F | |||
| 1 | 137135844 | 137135844 | 1 | 141 | T | T | F | F | F | 5 | 55484917 | 55484946 | 30 | 278 | T | T | F | F | F | |||
| 1 | 165896307 | 165896311 | 5 | 680 | T | T | F | F | F | 5 | 90775650 | 90775650 | 1 | 61 | T | T | F | F | F | |||
| 1 | 183578162 | 183578162 | 1 | 542 | T | T | F | F | F | 5 | 96571457 | 96571457 | 1 | 94 | T | T | F | F | F | |||
| 2 | 3736957 | 3736957 | 1 | 57 | T | T | F | F | F | 5 | 102062273 | 102062273 | 1 | 190 | T | T | F | F | F | |||
| 2 | 5040747 | 5040747 | 1 | 133 | T | T | F | F | F | 5 | 104084656 | 104084656 | 1 | 340 | T | T | F | F | F | |||
| 2 | 10336587 | 10336592 | 6 | 264 | T | T | F | F | F | 5 | 108572496 | 108572496 | 1 | 441 | T | T | F | F | F | |||
| 2 | 11688991 | 11689010 | 20 | 549 | F | T | F | F | T | 5 | 117528325 | 117528325 | 1 | 380 | T | T | F | F | F | |||
| 2 | 13697711 | 13697711 | 1 | 431 | F | T | T | F | F | 5 | 119304743 | 119304775 | 33 | 110 | T | T | F | F | F | |||
| 2 | 28188305 | 28188305 | 1 | 361 | F | T | F | F | T | 5 | 125695123 | 125695137 | 15 | 211 | T | T | F | F | F | |||
| 2 | 32226478 | 32226493 | 16 | 147 | F | T | T | F | F | 5 | 141144023 | 141144023 | 1 | 246 | T | T | T | F | F | |||
| 2 | 58517611 | 58517618 | 8 | 270 | T | T | F | F | F | 5 | 148185214 | 148185214 | 1 | 54 | F | F | F | F | NA | |||
| 2 | 61489637 | 61489637 | 1 | 643 | T | T | F | F | F | 6 | 18095110 | 18095110 | 1 | 159 | T | T | F | F | F | |||
| 2 | 72241857 | 72241857 | 1 | 462 | T | T | F | F | F | 6 | 36814629 | 36814629 | 1 | 299 | T | T | F | F | F | |||
| 2 | 74937052 | 74937064 | 13 | 384 | T | T | F | F | F | 6 | 39355424 | 39355448 | 25 | 176 | F | T | T | F | F | |||
| 2 | 78357403 | 78357403 | 1 | 50 | T | T | F | F | F | 6 | 101509677 | 101509677 | 1 | 148 | T | T | F | F | F | |||
| 2 | 79679676 | 79679676 | 1 | 330 | T | T | F | F | F | 6 | 103949614 | 103949614 | 1 | 122 | T | T | T | F | F | |||
| 2 | 85528071 | 85528071 | 1 | 131 | T | T | F | F | F | 6 | 115864297 | 115864297 | 1 | 315 | F | T | T | F | F | |||
| 2 | 96760589 | 96760589 | 1 | 169 | T | T | F | F | F | 6 | 128995778 | 128995882 | 105 | 337 | T | T | F | F | F | |||
| 2 | 116516318 | 116516318 | 1 | 126 | F | T | F | F | T | 6 | 134249703 | 134249745 | 43 | 388 | T | T | F | T | Dd | |||
| 2 | 135984537 | 135984537 | 1 | 46 | F | T | F | F | T | 17 | 14350774 | 14350820 | 47 | 587 | T | T | F | F | F | |||
| 2 | 147805390 | 147805390 | 1 | 383 | T | T | F | F | F | 17 | 25991437 | 25991437 | 1 | 162 | F | T | F | F | T | |||
| 2 | 150590002 | 150590002 | 1 | 687 | T | T | F | F | F | 17 | 31984106 | 31984106 | 1 | 113 | F | T | T | F | F | |||
| 2 | 166617293e | 166617524e | 232 | 370 | F | T | F | F | T | 17 | 51576043 | 51576050 | 8 | 491 | F | T | F | F | T | |||
| 3 | 16828944 | 16828944 | 1 | 267 | T | T | F | F | F | 17 | 67796579 | 67796615 | 37 | 97 | F | F | F | F | NA | |||
| 3 | 22128566 | 22128566 | 1 | 378 | T | F | F | F | NA | 17 | 79667734 | 79667734 | 1 | 258 | T | T | T | T | Dd | |||
| 3 | 36830205 | 36830205 | 1 | 492 | T | T | F | F | F | 18 | 4596959 | 4596972 | 14 | 394 | T | T | F | F | F | |||
| 3 | 51188409 | 51188409 | 1 | 182 | T | T | F | F | F | 18 | 28878184 | 28878184 | 1 | 305 | T | F | F | F | NA | |||
| 3 | 65603278 | 65603278 | 1 | 662 | T | T | F | F | F | 18 | 32083435 | 32083435 | 1 | 46 | T | T | F | F | F | |||
| 3 | 65655136 | 65655136 | 1 | 466 | F | T | F | F | T | 18 | 38278002 | 38278002 | 1 | 251 | T | T | F | F | F | |||
| 3 | 69739785 | 69739785 | 1 | 232 | T | T | F | F | F | 18 | 40885813 | 40885839 | 27 | 230 | T | T | F | F | F | |||
| 3 | 85792585 | 85792585 | 1 | 138 | T | T | F | F | F | 18 | 41946723 | 41946739 | 17 | 162 | T | T | F | F | F | |||
| 3 | 95869211 | 95869211 | 1 | 36 | T | T | F | F | F | 18 | 78715451 | 78715451 | 1 | 72 | F | T | F | F | T | |||
| 3 | 107617094 | 107617095 | 2 | 185 | T | T | F | F | F | 19 | 4199635 | 4199635 | 1 | 183 | T | T | F | F | F | |||
| 3 | 130702831 | 130702831 | 1 | 177 | T | T | F | F | F | 19 | 16998839 | 16998847 | 9 | 130 | F | T | F | F | T | |||
| 3 | 136064382 | 136064385 | 4 | 622 | F | T | F | F | T | 19 | 28429944 | 28429944 | 1 | 112 | T | T | F | F | F | |||
| 4 | 6396524 | 6396541 | 18 | 399 | F | T | F | F | T | 19 | 28519574 | 28519585 | 12 | 97 | T | T | F | F | F | |||
| 4 | 10936243 | 10936243 | 1 | 448 | F | T | F | F | T | 19 | 44938647 | 44938648 | 2 | 444 | T | T | F | F | F | |||
| 4 | 49528333 | 49528367 | 35 | 225 | T | T | F | F | F | X | 42581841 | 42581841 | 1 | 239 | T | T | F | F | F | |||
| 4 | 59369670 | 59369670 | 1 | 286 | T | T | F | F | F | X | 52427650 | 52427650 | 1 | 220 | F | T | F | F | T | |||
| 4 | 83240097 | 83240097 | 1 | 260 | F | T | F | F | T | X | 63297750 | 63297750 | 1 | 193 | F | F | F | F | NA | |||
F, false; T, true, NA, not applicable.
a
DMC1 colocalization; data from Davies et al. (2016) and Smagulova et al. (2016), overlap within ±1000 bp from DMC1 center.
b
Minimal and Maximal NCO conversion tract lengths.
c
The nonparental event is defined as found in (B6×PWD)F1 but not in parental B6 nor PWD DMC1 datasets.
d
Default hotspot; i.e. present in B6.Prdm9−/− DMC1 dataset.
e
Complex NCO event, see the main text.