Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 25;11:651921. doi: 10.3389/fonc.2021.651921

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Liu, Hou, Hu, Zhou, Chen, Yang and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mechanism of SLC39A8/zinc inhibiting cell migration and invasion. (A) GSEA showed that the group with low expression of SLC39A8 was significantly associated with HDAC and metastasis pathway. (B) Western blotting experiments detected the effect of SLC39A8/zinc on EMT in ccRCC cells. 786-O and OSRC-2 cells transfected with si−SLC39A8 (knockdown), SLC39A8 (overexpression), and their corresponding control were used for this study. (C) A possible mechanism for SLC39A8/zinc inhibits the EMT of ccRCC cells. HDAC, histone deacetylase; EMT, epithelial-mesenchymal transition; ICAM-1, intercellular adhesion molecule 1; AP-N, aminopeptidase N; NF-kB, nuclear factor kappa B; VEGF, vascular endothelial growth factor; IL-8, interleukin 8; MMP-9, matrix metallopeptidase 9; HIF-1α, hypoxia inducible factor-1α; ERK1/2, extracellular signal-regulated kinase 1/2.