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. 2021 Mar 25;11:651921. doi: 10.3389/fonc.2021.651921

Table 2.

Univariate and multivariate analyses of ZIP family genes mRNA level and patient disease-free survival.

Variable Univariate analysis Multivariate analysis
HR 95%CI P-value HR 95%CI P-value
SLC39A1 1.422 0.995–2.033 0.053
SLC39A2 1.334 0.936–1.901 0.111
SLC39A3 1.299 0.912–1.851 0.147
SLC39A4 1.011 0.711–1.439 0.950
SLC39A5 0.593 0.415–0.848 0.004 0.503 0.302–0.838 0.008
SLC39A6 1.071 0.752–1.525 0.705
SLC39A7 1.119 0.786–1.593 0.532
SLC39A8 0.406 0.278–0.594 0.000 0.481 0.275–0.841 0.010
SLC39A9 0.481 0.335–0.691 0.000 0.810 0.485–1.353 0.421
SLC39A10 0.777 0.546–1.106 0.161
SLC39A11 1.928 1.338–2.776 0.000 0.716 0.399–1.285 0.263
SLC39A12 0.855 0.592–1.234 0.403
SLC39A13 1.790 1.252–2.559 0.001 1.037 0.609–1.765 0.895
SLC39A14 1.573 1.095–2.259 0.014 1.326 0.769–2.287 0.310
Age 1.343 0.945–1.911 0.100
Gender 1.389 0.939–2.056 0.100
T stage 2.517 2.043–3.102 0.000 0.805 0.434–1.494 0.493
N stage 4.690 2.293–9.592 0.000 1.901 0.857–4.218 0.114
M stage 8.595 5.918–12.483 0.000 1.340 0.519–3.460 0.545
TNM stage 2.678 2.247–3.191 0.000 2.391 1.215–4.706 0.012
Grade 3.026 2.345–3.904 0.000 1.319 0.907–1.918 0.148

HR, hazard ratio; CI, confidence interval; TNM, Tumor Node Metastasis. Mean differences were considered statistically significant when P <0.05.